Normotensive patients with obstructive sleep apnoea: changes in 24-h ambulatory blood pressure monitoring with continuous positive airway pressure treatment

Journal of Hypertension
Esther Sapiña-BeltránMireia Dalmases

Abstract

Continuous positive airway pressure (CPAP) treatment reduces blood pressure (BP) in obstructive sleep apnoea (OSA) and hypertensive patients, but there is a lack of data about the effects of CPAP on the BP in normotensive patients. The aim of the study was to evaluate BP changes in normotensive OSA individuals receiving CPAP treatment. We selected 131 normotensive outpatients with an apnoea/hypopnoea index (AHI) greater than 15 events/hour who required CPAP treatment. All patients underwent a sleep study and 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. In addition, the patients were assessed for the presence of baseline masked hypertension, defined as office BP less than 140/90 mmHg and increased BP on 24-h ABPM (mean 24-h BP ≥130/80 mmHg). After 6 months of CPAP treatment, a mild reduction in all 24-h ABPM variables was observed, but only the mean 24-h DBP [-1.39 mmHg, 95% confidence interval (95% CI), -2.50 to -0.27], mean daytime DBP (-1.39 mmHg, 95% CI -2.56 to -0.22) and the mean 24-h ambulatory BP (-1.80 mmHg, 95% CI, -3.16 to -0.44) reached statistical significance. The reduction was primarily due to BP changes in individuals with masked hypertension who displayed a mean BP reduction of -4.78 mmHg...Continue Reading

References

Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J F FaccendaN J Douglas
Oct 6, 2001·American Journal of Hypertension·J S LoredoJ E Dimsdale
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Feb 22, 2007·The Canadian Journal of Cardiology·Faye S RoutledgeUNKNOWN Canadian Hypertension Society
Aug 1, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Thomas G PickeringKazuomi Kario
Dec 15, 2007·Chest·Sandro Cadaval GonçalvesFlávio Danni Fuchs
Jan 30, 2008·Hypertension·Suraj KapaVirend K Somers
Apr 10, 2008·Journal of Hypertension·Jean-Philippe BaguetJean-Louis Pépin
Aug 16, 2008·International Review of Cell and Molecular Biology·Geoffrey E Woodard, Juan A Rosado
Dec 19, 2009·American Journal of Hypertension·Luciano F DragerEduardo M Krieger
Jun 4, 2010·Journal of Hypertension·Hong-Qi FanUNKNOWN International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators
Sep 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jacek WolfKrzysztof Narkiewicz
Mar 15, 2011·Archivos de bronconeumología·Patricia LloberesJoaquín Terán-Santos
Dec 11, 2013·The Lancet. Respiratory Medicine·Manuel Sánchez-de-la-TorreFerran Barbé
Dec 12, 2013·JAMA : the Journal of the American Medical Association·Miguel-Angel Martínez-GarcíaUNKNOWN Spanish Sleep Network
Mar 13, 2015·Journal of Human Hypertension·C GonzagaD Calhoun
Apr 17, 2015·Chest·Gerard TorresFerran Barbé
Jul 25, 2015·The Journal of Clinical Hypertension·Gerard TorresFerran Barbé
Sep 1, 2015·Journal of the American College of Cardiology·Manuel Sánchez-de-la-TorreUNKNOWN Spanish Sleep Network

❮ Previous
Next ❯

Citations

Apr 2, 2020·Frontiers in Physiology·Richard StaatsCristina Bárbara
Jun 18, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomotake Tokunou, Shin-Ichi Ando
May 18, 2019·The European Respiratory Journal·Esther Sapiña-BeltránUNKNOWN Spanish Sleep and Breathing Group
May 24, 2019·Current Hypertension Reports·Marissa A BowmanMartica H Hall
Dec 30, 2020·The Journal of Clinical Hypertension·Kouichi TamuraTomoaki Ishigami
Jul 17, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Nazia Naz S KhanAdesuwa Olomu
Dec 26, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Esther Sapiña-BeltránMireia Dalmases

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.