Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
Jordan J NostedtD Bigam

Abstract

As a result of donation after circulatory death liver grafts' poor tolerance to cold storage, there has been increasing research interest in normothermic machine perfusion. This study aims to systematically review the current literature comparing normothermic perfusion to cold storage in donation after circulatory death liver grafts and complete a meta-analysis of published large animal and human studies. A total of nine porcine studies comparing cold storage to normothermic machine perfusion for donation after circulatory death grafts were included for analysis. There was a significant reduction in AST (mean difference -2291 U/L, CI (-3019, -1563); P ≤ 0.00001) and ALT (mean difference -175 U/L, CI (-266, -85); P = 0.0001), for normothermic perfusion relative to static cold storage, with moderate (I2 = 61%) and high (I2 = 96%) heterogeneity, respectively. Total bile production was also significantly higher (mean difference = 174 ml, CI (155, 193); P ≤ 0.00001). Further research focusing on standardization, performance of this technology following periods of cold storage, economic implications, and clinical trial data focused on donation after circulatory death grafts will be helpful to advance this technology toward routine cl...Continue Reading

References

Apr 26, 2002·The British Journal of Surgery·S D St PeterP J Friend
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ronald W Busuttil, Koichi Tanaka
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Srikanth ReddyPeter Friend
Dec 20, 2005·Journal of Clinical Epidemiology·Toshi A FurukawaNorio Watanabe
Oct 24, 2007·Transplantation Proceedings·K VekemansD Monbaliu
Dec 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J V GuarreraJ C Emond
Aug 25, 2011·Annals of Surgery·Constantino FondevilaJuan C García-Valdecasas
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S op den DriesR J Porte
Apr 27, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T MinorB Lüer
May 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M U BoehnertM Selzner
Jun 19, 2013·Transplantation Proceedings·H ObaraH Mizunuma
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M U BoehnertM Selzner
Mar 29, 2014·BMC Medical Research Methodology·Carlijn R HooijmansMiranda W Langendam
May 9, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Qiang LiuCristiano Quintini
Sep 3, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jan M KnaakMarkus Selzner
Apr 8, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Reena RavikumarPeter J Friend
Oct 7, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Babak BananWilliam Chapman
Dec 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q LiuC Quintini
Jan 12, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R RavikumarP J Friend
Mar 31, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Babak BananWilliam Chapman
Apr 19, 2016·Artificial Organs·Ahmed NassarCristiano Quintini
Oct 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H MergentalD F Mirza
Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Markus SelznerDavid R Grant
Oct 22, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M BralA M J Shapiro
Nov 4, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas VogelPeter J Friend
Aug 5, 2017·Clinical Transplantation·Jessica C CoffeyRoberto Hernandez-Alejandro

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