Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice.

Nature Communications
A. N. RothStephanie M Karst

Abstract

Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a norovirus small animal disease model in wild-type mice. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response.

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Citations

Aug 23, 2020·Viruses·Heyde MakimaaMegan T Baldridge
Nov 13, 2020·Journal of Virology·Vincent R GrazianoCraig B Wilen
Aug 29, 2021·Viruses·Louisa F Ludwig-BegallEtienne Thiry

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Datasets Mentioned

BETA
KC792553
JQ237823.1

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BETA
biopsies

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