Norovirus P particle: an excellent vaccine platform for antibody production against Alzheimer's disease

Immunology Letters
Lu FuWei Kong

Abstract

Active vaccination against amyloid β (Aβ42) is considered a potential therapeutic approach for Alzheimer's disease (AD). However, immunization with synthetic human Aβ1-42 has resulted in meningoencephalitis in 6% of patients and generated only low-titer anti-Aβ42 antibodies. In order to develop a safe and effective vaccine against Alzheimer's disease, the Aβ1-6 peptide was used as the novel immunogen and Norovirus P particles as the vaccine platform in this study. By inserting and presenting Aβ1-6 on the outermost surface of the P particle, we showed that the chimeric P particle-based AD protein vaccine could elicit a strong immune response, inducing highly specific antibody titers against Aβ42 without causing T-cell activation. Furthermore, antibodies induced by the AD protein vaccines were demonstrated to be effective at the cellular level. In addition, we also compared the immunogenicity of the chimeric P particles with different insertional loci in the loop structure domain and demonstrated that insertion of the antigen into all three loops of the P particle at the same time could significantly improve immune responses to the vaccine. In conclusion, the Norovirus P particle is an excellent vaccine platform for stimulating A...Continue Reading

References

Apr 1, 1997·Journal of Neuropathology and Experimental Neurology·D W Dickson
Aug 5, 2003·The Journal of Clinical Investigation·Alon MonsonegoHoward L Weiner
Sep 23, 2003·Brain Research. Brain Research Reviews·Craig S AtwoodRalph N Martins
Jan 15, 2005·Progress in Neurobiology·Carlos MorganNibaldo C Inestrosa
May 11, 2005·Immunological Reviews·Marc E WekslerPaul Szabo
May 11, 2005·Neurology·S GilmanUNKNOWN AN1792(QS-21)-201 Study Team
May 27, 2006·Neurobiology of Aging·Timothy J SeabrookCynthia A Lemere
Apr 10, 2009·Current Alzheimer Research·Bruno VellasUNKNOWN AN1792 (QS-21)-251 Study Team
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Feb 9, 2010·Nature Reviews. Neurology·Cynthia A Lemere, Eliezer Masliah
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christoph WiessnerMatthias Staufenbiel
Jan 24, 2012·Journal of Structural Biology·Jessica Z BereszczakAlbert J R Heck
Jul 31, 2013·Neuropharmacology·R AnandAbbas Ali Mahdi
Mar 20, 2015·Neuron·Thomas Wisniewski, Fernando Goñi

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