PMID: 15223821Jun 30, 2004Paper

Norrie gene product is necessary for regression of hyaloid vessels

Investigative Ophthalmology & Visual Science
Anne V OhlmannElke Lütjen-Drecoll

Abstract

To investigate the nature and origin of the vitreous membranes in mice with knock-out of the Norrie gene product (ND mice). Eighty-two eyes of ND mice of different age groups (postnatal day [P]0-13 months) and 95 age-matched wild-type control mice were investigated. In vitreoretinal wholemounts and in sagittal sections, vessels and free cells were visualized by labeling for lectin. In addition, staining with a marker for macrophages (F4/80) and collagen XVIII/endostatin known to be involved in regression of hyaloid vessels was performed for light and electron microscopic investigations. Endostatin expression was confirmed by Western blot analysis. Wild-type controls showed the typical pattern of hyaloid vessels, their regression and concomitantly retinal vasculogenesis and angiogenesis. Hyaloid vessels all stained for endostatin, whereas retinal vessels remained unstained. In ND mice, 1 to 5 days after birth, the hyaloid and retinal vasculatures were comparable to that in control mice. The hyaloid vessels also stained for endostatin. Numerous F4/80-positive cells were present adjacent to the vessels. With increasing age, only a few connecting branches of the hyaloid vessels regressed. Even in old mice most of the hyaloid vessel...Continue Reading

Citations

Jul 16, 2014·Japanese Journal of Ophthalmology·Eisuke AraiAkira Murakami
Jan 6, 2010·The Journal of Biological Chemistry·Malia M EdwardsPatsy M Nishina
Feb 16, 2010·Cardiovascular Research·Alicia G Arroyo, M Luisa Iruela-Arispe
Jun 13, 2008·The European Journal of Neuroscience·Ulrich F O LuhmannWolfgang Berger
Jan 23, 2010·Clinical & Experimental Ophthalmology·Barkur S Shastry
Aug 27, 2005·Experimental Eye Research·C A MayU H M Spandau
Mar 6, 2012·Progress in Retinal and Eye Research·Andreas Ohlmann, Ernst R Tamm
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander G Marneros, Bjorn R Olsen
Apr 19, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Mrinali P GuptaR V Paul Chan
May 23, 2006·Physiology·T Néstor H Masckauchán, Jan Kitajewski
Feb 10, 2007·Retina·Kimberly A DrenserMichael T Trese

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