Norton score and clinical outcomes following acute decompensated heart failure hospitalization.

Journal of cardiology
Sharon Shalom NatanzonIsrael Mazin

Abstract

Norton scoring system is used to assess frailty of hospitalized patients with various medical conditions. We aimed to evaluate whether admission Norton scoring system predicts adverse outcomes among heart failure patients. The study population comprised 4388 acute heart failure patients between the years 2008 and 2017. Patients were allocated to 3 groups according to their admission Norton score [(≤15-low, 16-18-intermediate, and ≥19-high)]. Primary outcome included all-cause mortality at 30, 90 days, and 1 year. Multivariate Cox proportional hazards regression modeling was used to assess the independent association between Norton score and mortality. Net reclassification improvement (NRI) analysis was used to asses Norton's additive predictive ability upon known prognostic factors. Among 4388 study patients, 32% (n=1611) had low Norton score, 28% (n=1384) intermediate score, and 40% (n=1900) high score. Kaplan-Meier analysis demonstrated significantly higher 30-day mortality among patients with a low Norton score as compared with those with intermediate or high score (2.6%, 6.3%, and 16.1%; log rank p<0.001). A similar trend was noted at 90 days and 1 year. Multivariate analysis found Norton score to be an independent predicto...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
May 4, 2001·The American Journal of Medicine·E J Eichhorn
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Douglas S LeeJack V Tu
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Nov 30, 2005·European Journal of Clinical Investigation·F CacciatoreF Rengo
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Aug 21, 2013·JACC. Heart Failure·Sheila M McNallanVéronique L Roger
Sep 10, 2013·The American Journal of Cardiology·Paloma GastelurrutiaAntoni Bayes-Genis
May 14, 2016·The Keio Journal of Medicine·Ken Shinmura
Mar 21, 2018·Revista clínica española·J Díez-ManglanoUNKNOWN en representación de los investigadores del estudio IMPIMI
Feb 11, 2019·JACC. Heart Failure·Jonathan AfilaloRita Mancini
Feb 11, 2019·JACC. Heart Failure·Shirley SzeAndrew L Clark
Oct 28, 2019·European Journal of Heart Failure·Cristiana VitaleAndrew J Coats
Dec 31, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Cristiana Vitale, Izabella Uchmanowicz

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Citations

Dec 8, 2020·Journal of cardiology·Toshihide Izumida, Teruhiko Imamura

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