Nortriptyline hydrochloride skin absorption: development of a transdermal patch

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
A MeleroU Schäfer

Abstract

The influence of propylen glycol (PG), ethanol, and oleic acid (OA) on nortriptyline hydrochloride (NTH) penetration through human epidermis was studied in vitro at two different pH values (5.5 and 7.4). The influence of lactic acid and polysorbate 80 was studied for a pH of 5.5. Permeation studies through Heat Separated Epidermis, as well as the enhancing effect of the different vehicles, showed a pH dependency. A pH value of 5.5 in the donor solution decreases significantly the permeability coefficient (Kp) with respect to a pH value of 7.4 (0.011+/-0.004 x 10(-6) versus 0.36+/-0.04 x 10(-6)cm/s). The vehicles showed an increasing enhancement effect in the order: polysorbate 80>ethanol/PG/OA>PG>ethanol>ethanol/lactic acid>lactic acid at pH 5.5 while they reduced the permeation of NTH at pH 7.4. Considering the results obtained at pH 5.5, the maximum enhancement ratios were found for polysorbate 80 and the combination ethanol/PG/OA (10.72 and 3.90). Both vehicles were selected for designing a NTH transdermal delivery system (NTH-TDS) using (hydroxypropyl)methyl-cellulose as polymer. The NTH-TDS based on the combination of ethanol/PG/OA showed an enhancement ratio with respect to control of 2.09 and the addition of polysorbate ...Continue Reading

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Citations

Aug 26, 2011·Drug Development and Industrial Pharmacy·Marina BorovinskayaFotios M Plakogiannis
Mar 5, 2011·Journal of Pharmaceutical Sciences·Steffi HansenGerald B Kasting
Jun 27, 2012·Journal of Pharmaceutical Sciences·Salem Seif, Steffi Hansen
Oct 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit AlexanderDulal Krishna Tripathi
Sep 29, 2009·International Journal of Pharmaceutics·Ana MeleroTeresa M Garrigues
Feb 10, 2010·Pharmaceutical Development and Technology·José Juan Escobar-ChávezMatilde Merino-Sanjuán
Dec 8, 2019·Drug Delivery and Translational Research·Juan J CarrerasAna Melero
Jan 22, 2021·Drug Delivery and Translational Research·Delly RamadonRyan F Donnelly

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