NOS2 as an Emergent Player in Progression of Cancer

Antioxidants & Redox Signaling
Douglas D Thomas, David A Wink

Abstract

Although the inducible form of nitric oxide synthase (NOS2) was initially shown to be a major player as an antitumor component of the immune response, more recent data have shown that NOS2 expression in cancer cells often predicts poor outcome. Unlike growth factors associated with a single oncogenic pathway, nitric oxide (NO) has a ubiquitous nature wherein it simultaneously mediates major oncogenic pathways from Akt/PI3K and RAS/ERK to HIF1a and TGFb. These interactive loops perpetuate oncogenic mechanism that leads to increased cancer stemness, proliferation metastasis, chemoresistance, angiogenesis, and immunosuppression. Examination of a wide variety of patient tumors demonstrates that NOS2 expression is >50% for most cancers. In many cases, elevated NOS2 has been shown to predict poor outcome in cancer such as ER- breast cancer, glioma, melanoma, cervical, liver, ovarian, and pancreatic. Taken together, NOS2 may be one of the most powerful biomarker and predictors of poor prognosis and an ideal target for cancer therapy. Antioxid. Redox Signal. 26, 963-965.

References

Jul 11, 1998·Carcinogenesis·D A WinkJ B Mitchell
Jul 22, 2008·Nitric Oxide : Biology and Chemistry·David A WinkCurtis C Harris
Dec 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A RidnourDavid A Wink
Jun 29, 2015·Free Radical Biology & Medicine·Douglas D ThomasKatrina M Miranda

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Citations

Aug 20, 2019·British Journal of Pharmacology·Ronghua WangTimothy R Billiar
Jun 23, 2019·International Journal of Molecular Sciences·Paola PalumboBenedetta Cinque
Sep 21, 2018·Frontiers in Oncology·Salvatore Rizza, Giuseppe Filomeni
Apr 11, 2018·Antioxidants & Redox Signaling·Veena SomasundaramDavid A Wink
Nov 5, 2019·Frontiers in Oncology·Nadezda LipunovaMaurice P Zeegers
Oct 6, 2020·The Biochemical Journal·Salvatore Rizza, Giuseppe Filomeni
Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariusz G FleszarMałgorzata Krzystek-Korpacka
Oct 30, 2020·Metabolites·Erika M PalmieriDaniel W McVicar
Feb 7, 2020·Antioxidants & Redox Signaling·Silvia VivarelliMassimo Libra
May 1, 2021·International Journal of Molecular Sciences·Vandana SharmaSaori Furuta
Aug 31, 2021·Neurochemistry International·Marek Mazurek, Radosław Rola
Oct 26, 2021·Inorganic Chemistry·Katrina M MirandaDavid A Wink

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Methods Mentioned

BETA
transfection

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