Nosema ceranae alters a highly conserved hormonal stress pathway in honeybees

Insect Molecular Biology
Christopher MayackD P McMahon

Abstract

Nosema ceranae, an emerging pathogen of the western honeybee (Apis mellifera), is implicated in recent pollinator losses and causes severe energetic stress. However, whether precocious foraging and accelerated behavioural maturation in infected bees are caused by the infection itself or via indirect energetic stress remains unknown. Using a combination of nutritional and infection treatments, we investigated how starvation and infection alters the regulation of adipokinetic hormone (AKH) and octopamine, two highly conserved physiological pathways that respond to energetic stress by mobilizing fat stores and increasing search activity for food. Although there was no response from AKH when bees were experimentally infected with N. ceranae or starved, supporting the notion that honeybees have lost this pathway, there were significant regulatory changes in the octopamine pathway. Significantly, we found no evidence of acute energetic stress being the only cause of symptoms associated with N. ceranae infection. Therefore, the parasite itself appears to alter regulatory components along a highly conserved physiological pathway in an infection-specific manner. This indicates that pathogen-induced behavioural alteration of chronically ...Continue Reading

References

Oct 9, 2002·Hormones and Behavior·David J SchulzGene E Robinson
Feb 4, 2003·Brain, Behavior and Evolution·David J SchulzGene E Robinson
Feb 4, 2003·Brain, Behavior and Evolution·Shelley A Adamo
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gro V AmdamRobert E Page
Jul 1, 2006·The Journal of Experimental Biology·Herman K LehmanGene E Robinson
Jan 16, 2007·Journal of Invertebrate Pathology·Mariano HigesAránzazu Meana
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrew B BarronGene E Robinson
May 8, 2007·Neurochemical Research·Tahira Farooqui
Jun 19, 2007·Journal of Insect Physiology·Tugrul GirayDevrim Oskay
Jul 1, 2008·General and Comparative Endocrinology·Angela B Lange
Jul 24, 2008·Environmental Microbiology·Mariano HigesAránzazu Meana
Jan 13, 2009·Journal of Invertebrate Pathology·Christopher Mayack, Dhruba Naug
Aug 14, 2009·Cellular Microbiology·Bryony A P Williams
Jan 7, 2010·Environmental Microbiology·Cédric AlauxYves Le Conte
Aug 6, 2010·Journal of Insect Physiology·Christopher Mayack, Dhruba Naug
Dec 16, 2010·Journal of Invertebrate Pathology·Cédric AlauxYves Le Conte
Jan 27, 2011·PloS One·Irina SinakevitchBrian H Smith
Oct 18, 2011·Journal of Invertebrate Pathology·Matthew D Smart, Walter S Sheppard
Mar 13, 2012·Peptides·Jan A VeenstraRobert J Weaver
Mar 20, 2012·Journal of Invertebrate Pathology·Cristina BotíasMariano Higes
Jan 17, 2013·Journal of Invertebrate Pathology·Wei-Fone Huang, Leellen F Solter
Jun 13, 2013·Environmental Microbiology Reports·Mariano HigesRaquel Martín-Hernández
Jul 27, 2014·The Journal of Experimental Biology·Cédric AlauxYves Le Conte
Jan 1, 2012·Insects·Naïla EvenAndrew B Barron

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Citations

Jul 12, 2016·Behavioral Ecology and Sociobiology·Myrsini E NatsopoulouRobert J Paxton
Jun 24, 2016·Environmental Microbiology Reports·Trish WellsAlison J Haughton
Feb 15, 2018·International Journal of Molecular Sciences·Elisabeth MarchalHeleen Verlinden
Mar 27, 2018·Environmental Microbiology·Raquel Martín-HernándezMariano Higes
Aug 18, 2017·The Journal of Experimental Biology·Melissa A Bernardo, Michael S Singer
Jan 24, 2018·The Journal of Experimental Biology·Stephanie L GageGloria DeGrandi-Hoffman
Mar 7, 2020·The Journal of Experimental Biology·Vanessa Corby-HarrisBethany T Obernesser
May 17, 2018·Frontiers in Microbiology·Guilin LiXingqi Guo
Apr 9, 2020·Frontiers in Neuroscience·Stephanie L GageGloria DeGrandi-Hoffman
Apr 30, 2021·Frontiers in Veterinary Science·Timothy C CameronTravis Beddoe
May 20, 2021·Royal Society Open Science·Christopher MayackAnthony Macherone

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