Abstract
The incidence of bloodstream infection (BSI) varies according to the transplanted organ. Mortality can be as high as 24%, with a significant impact on graft survival. Transplantation is a risk factor for multidrug-resistant (MDR) organisms, but comparison with a non-transplanted population in a single large cohort has not been described. This is a prospective nationwide study (16 centers) reporting data on 2364 monomicrobial nosocomial BSIs, comparing 83 episodes in solid organ transplant patients with 2447 BSIs occurring in the general hospital population. The prevalence of groups of infecting organisms (gram-positive, gram-negative, and fungi) was similar between transplant patients and the general population and a similar crude mortality rate was observed (34.9% in transplant vs. 43.3% in non-transplant patients). Staphylococcus aureus was the single most frequently isolated organism in both groups, and Acinetobacter species was more frequently isolated in the general population. Regarding MDR organisms, Klebsiella species, and Enterobacter species resistant to cefepime, as well as Acinetobacter species resistant to meropenem, were significantly more frequent in transplant patients. Antimicrobial resistance is higher, partic...Continue Reading
References
Jun 27, 2000·Transplantation·S M PalmerV F Tapson
May 19, 2001·American Journal of Nephrology·K C AbbottL Y Agodoa
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Jan 3, 2006·Transplantation Proceedings·F J CandelA Moreno
Mar 7, 2006·The Journal of Hospital Infection·S R P E DantasM L Moretti
Aug 10, 2006·BMC Infectious Diseases·Natalie BergerHugo Bonatti
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A MorenoJ Carratalá
Dec 19, 2007·Antimicrobial Agents and Chemotherapy·Mitchell J SchwaberYehuda Carmeli
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M N Al-HasanL M Baddour
Jun 6, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Khetam HusseinRenato Finkelstein
Jul 30, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S H ShiS S Zheng
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C van DeldenUNKNOWN AST Infectious Diseases Community of Practice
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C Garzoni, UNKNOWN AST Infectious Diseases Community of Practice
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasTom M Chiller
Jun 30, 2010·Transplantation·Moacyr SilvaLuis F A Camargo
Jul 8, 2010·Lung·D R NunleyA L Pope-Harman
Oct 12, 2010·Current Opinion in Organ Transplantation·Gopi PatelRobert A Bonomo
Mar 18, 2011·Journal of Clinical Microbiology·Alexandre R MarraUNKNOWN Brazilian SCOPE Study Group
Mar 18, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sang-Oh LeeRaymund R Razonable
Apr 5, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ron-Bin HsuShu-Hsun Chu
Apr 16, 2011·Transplantation·Majdi N Al-HasanLarry M Baddour
Citations
Apr 21, 2016·The Medical Clinics of North America·William G Greendyke, Marcus R Pereira
Jan 29, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·B M BerengerS W Smith
May 22, 2016·Infectious Disease Clinics of North America·Donald M Dumford, Marion Skalweit
Nov 5, 2016·Diagnostic Microbiology and Infectious Disease·Rossana RosaLilian M Abbo
May 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonathan Hand, Gopi Patel
May 14, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Isabel OriolJordi Carratalà
Jan 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Thomas SchachtnerPetra Reinke
Apr 26, 2018·International Journal of Molecular Sciences·Federica Del ChiericoLorenza Putignani
Sep 4, 2018·Epidemiology and Infection·H G Ternavasio-de la VegaM Marcos
May 19, 2019·Clinical Transplantation·Stephanie M PouchUNKNOWN AST Infectious Diseases Community of Practice
Nov 24, 2019·Journal of Thrombosis and Haemostasis : JTH·Marijke PeetermansPeter Verhamme
Mar 17, 2020·The Journal of Infectious Diseases·Tingting XiaoYonghong Xiao
May 11, 2016·Journal of Breath Research·Christiaan A ReesJane E Hill
Aug 2, 2016·Transplantation·J Alexander ViehmanM Hong Nguyen
May 25, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John P DonnellyHenry E Wang
Mar 27, 2019·Intensive Care Medicine·Jean-François TimsitChristian Van Delden
Sep 27, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Madeleine R HeldmanMichael G Ison
Mar 21, 2020·Transplantation·Zita Galvin
Mar 17, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rebecca WangJudith A Anesi
Apr 4, 2021·Pathogens·Daniella Renata FariaErika Seki Kioshima
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Diana F Florescu, Andre C Kalil