Abstract
Four cases of fatal disseminated Scedosporium prolificans (inflatum) infection occurring in neutropenic patients are reported. Because of hospital renovation, the patients were cared for in a temporary hematologic facility. S. prolificans (inflatum) was isolated from blood cultures of these four patients, two of whom underwent full necropsy, and revealed abundant vegetative hyphae and ovoid conida with truncate bases in many organs. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to amphotericin B, flucytosine, miconazole, ketoconazole, fluconazole, and itraconazole, with MICs greater than 16 micrograms/ml. The reported infections, two in each of two rooms, occurred over a period of 1 month, with very similar clinical outcomes. Circumstancial evidence suggested a nosocomial outbreak, but the environmental samples collected from the rooms, corridors, and adjacent areas did not yield S. prolificans (inflatum). Nevertheless, circumstantial evidence suggested a nosocomial outbreak of S. prolificans (inflatum) infection.
References
Jul 1, 1992·Pediatric Hematology and Oncology·S A SparrowD L Baker
May 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G M WoodM Harrison
Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E Anaissie
Nov 1, 1991·Journal of Clinical Microbiology·J L Rodriguez-Tudela, P Aviles
Sep 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J MarinJ L Menezo
Feb 1, 1991·Journal of Clinical Microbiology·A Espinel-Ingroff, T M Kerkering
Aug 1, 1990·Southern Medical Journal·E C ToyE R Leibovitch
Jan 1, 1990·The Journal of Infectious Diseases·C M WilsonI F Salkin
May 1, 1990·The Pediatric Infectious Disease Journal·M MalekzadehM Hirsch
Jun 1, 1989·European Journal of Epidemiology·T J Walsh, D M Dixon
Apr 1, 1989·Mycopathologia·R C SummerbellJ Kane
May 1, 1988·Antimicrobial Agents and Chemotherapy·H J SchmittD Armstrong
Mar 1, 1988·Journal of Clinical Microbiology·I F SalkinM G Rinaldi
Aug 1, 1985·Mayo Clinic Proceedings·L B TravisW R Wilson
Sep 1, 1982·American Journal of Epidemiology·J R LentinoM W Rytel
Oct 1, 1994·Journal of Clinical Microbiology·P A LennonS B Lee
Mar 1, 1994·Mycoses·G S de HoogE Guého
May 1, 1994·British Journal of Haematology·M TapiaA Zubizarreta
Jan 1, 1994·Antimicrobial Agents and Chemotherapy·J L Rodriguez-Tudela, J V Martinez-Suarez
Sep 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P H McWhinneyH G Prentice
Oct 1, 1993·The Pediatric Infectious Disease Journal·K NielsenJ D Cherry
Jan 1, 1993·Scandinavian Journal of Infectious Diseases·R SalesaJ Ponton
Citations
Jun 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M C FeltkampE J Kuijper
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P IdigorasJ M González
Apr 12, 2003·Leukemia & Lymphoma·Naoya OchiaiMasao Nakagawa
Jan 27, 2004·Bone Marrow Transplantation·S McCannUNKNOWN Infectious Diseases Working Party of the EBMT
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay G Revankar, Deanna A Sutton
May 21, 2015·European Journal of Clinical Investigation·Setareh DavoudiDimitrios P Kontoyiannis
Mar 31, 2016·International Journal of Molecular Sciences·Ayat Al-LaaeibyChristopher R Thornton
Nov 27, 2002·Journal of Medical Microbiology·M OrtonedaJ Guarro
Jul 1, 2008·Internal Medicine Journal·C C ChangM A Slavin
Jun 25, 2015·BioMed Research International·Laura Elena Carreto-BinaghiMaria Lucia Taylor
Apr 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hajime KanamoriDavid J Weber
Jun 30, 2016·Memórias do Instituto Oswaldo Cruz·Thaís Pereira de MelloAndré Luis Souza Dos Santos
Jul 1, 1997·Medicine·J BerenguerJ V Martinez-Suarez
Jul 14, 2005·Medical Mycology·Cristina Gil-LamaignereEmmanuel Roilides
Jan 19, 2008·Clinical Microbiology Reviews·Karoll J CortezThomas J Walsh
Feb 9, 2008·Emerging Infectious Diseases·Laurence DelhaesWieland Meyer
Apr 2, 2014·Environmental Microbiology·Christopher R ThorntonDarren M Soanes
Jun 6, 2013·Critical Reviews in Microbiology·Christopher R Thornton, Odette E Wills
Dec 9, 2014·Internal Medicine Journal·C C ChangM A Slavin
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shahid HusainNina Singh
Nov 27, 2001·Clinical & Experimental Ophthalmology·P A McKelvieA J Hall
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Joseph MeletiadisUNKNOWN EUROFUNG Network
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Rosie BocanegraJohn R Graybill
Feb 25, 1999·Revista Do Instituto De Medicina Tropical De São Paulo·C M MachadoF L Dulley
Nov 26, 2008·Medical Mycology·Juan Luis Rodriguez-TudelaManuel Cuenca-Estrella
Jun 8, 2001·Journal of the American Veterinary Medical Association·T W SwerczekR J Hunt
Aug 25, 1999·FEMS Immunology and Medical Microbiology·B Ruiz-Díez, J V Martínez-Suárez
Mar 15, 2018·Medical Mycology·Andoni Ramirez-GarciaFernando L Hernando
Mar 27, 2021·Clinical Case Reports·Yoshitsugu SugiuraTadahiko Matsumoto
Aug 10, 2001·Medical and Pediatric Oncology·D Barbaric, P J Shaw
Apr 4, 2000·Journal of Clinical Microbiology·J de BatlleR Ortiz
Sep 1, 1997·Journal of Clinical Microbiology·R San MillánJ Pontón
Jun 1, 1996·Infectious Disease Clinics of North America·R L Sandin, M Rinaldi
Aug 20, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F BosmaP E Verweij