Nosocomial outbreak of neonatal Salmonella enterica serotype Enteritidis meningitis in a rural hospital in northern Tanzania

BMC Infectious Diseases
Hogne VaaglandNina Langeland

Abstract

Clinicians at Haydom Lutheran Hospital, a rural hospital in northern Tanzania noted an unusually high case-fatality rate of pediatric meningitis and suspected an outbreak of an unknown agent or an organism resistant to the empirical therapy. We established a provisional microbiology laboratory to investigate the suspected outbreak. Blood and spinal fluid specimens were taken from children below the age of seven years with suspected meningitis. The blood and spinal fluid specimens were inoculated in commercial blood culture bottles and locally prepared Thayer-Martin medium in slanted tubes, respectively. The bacterial isolates were sent to Norway for further investigation, including susceptibility testing and pulsed-field gel-electrophoresis (PFGE). Among 24 children with suspected meningitis and/or septicemia, five neonates had meningitis caused by Salmonella enterica serotype Enteritidis, all of whom died. Two children had S. Enteritidis septicemia without meningitis and both survived. Genotyping with PFGE suggested a clonal outbreak. The salmonella strain was resistant to ampicillin and sensitive to gentamicin, the two drugs commonly used to treat neonatal meningitis at the hospital. The investigation reminds us that nontypho...Continue Reading

References

Sep 1, 1991·The Pediatric Infectious Disease Journal·M A KhanA Ghafoor
Jun 1, 1985·Infection Control : IC·C S Weikel, R L Guerrant
Aug 1, 1993·The Pediatric Infectious Disease Journal·R WessalowskiT Voit
Mar 6, 1997·The New England Journal of Medicine·V J Quagliarello, W M Scheld
May 29, 2000·Annals of Tropical Paediatrics·E M MolyneuxM E Molyneux
Jan 6, 2001·The Pediatric Infectious Disease Journal·S M GrahamC A Hart
Jun 23, 2001·The Pediatric Infectious Disease Journal·S SirinavinM Vorachit
Feb 16, 2002·Acta Obstetricia Et Gynecologica Scandinavica·S G HinderakerO H Olsen

❮ Previous
Next ❯

Citations

May 7, 2009·Indian Journal of Pediatrics·Murat AnilNeval Agus
Apr 6, 2006·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Magdalena WiesnerClara Inés Agudelo
Jun 20, 2012·Emerging Infectious Diseases·Irene RodríguezKatie L Hopkins
Mar 8, 2012·Future Microbiology·Nina M van Sorge, Kelly S Doran
Oct 2, 2009·Tropical Medicine & International Health : TM & IH·Inácio MandomandoPedro L Alonso
Jul 31, 2019·Antimicrobial Agents and Chemotherapy·Mathieu ClémentAndrea Endimiani
Nov 28, 2012·Indian Journal of Medical Microbiology·B A FomdaM I Naik

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
genotyping

Software Mentioned

Stata

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Transactions of the Royal Society of Tropical Medicine and Hygiene
A L WalshS M Graham
Jornal de pediatria
Sidnei FerreiraAntonio Jose Ledo A Cunha
Respirology : Official Journal of the Asian Pacific Society of Respirology
Ignacio Martin-LoechesH1N1 SEMICYUC Working Group
© 2021 Meta ULC. All rights reserved