PMID: 8596225Mar 20, 1996Paper

Nosocomial pneumonia and mortality among patients in intensive care units

JAMA : the Journal of the American Medical Association
J Y FagonC Gibert

Abstract

To evaluate the role that nosocomial pneumonia plays in the outcome of intensive care unit (ICU) patients. Cohort study. Medical ICU, Hôpital Bichat, Paris, France, an academic tertiary care center. A total of 1978 consecutive patients admitted to the ICU for at least 48 hours. Various parameters known to be strongly associated with death of ICU patients were recorded: age, location before admission to the ICU, diagnostic categories, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Simplified Acute Physiologic Score, McCabe score, number and type of dysfunctional organs, and the development of nosocomial bacteremia and nosocomial urinary tract infection. These variables and the presence or absence of nosocomial pneumonia were compared between survivors and nonsurvivors and entered into a stepwise logistic regression model to evaluate their independent prognostic roles. Nosocomial pneumonia developed in 328 patients (16.6%) whose mortality was 52.4% compared with 22.4% for patients without ICU-acquired pneumonia (P < .001), APACHE II score (odds ratio [OR] = 1.08; 95% confidence interval [CI], 1.06 to 1.10; P < .001), number of dysfunctional organs (OR = 1.54; 95% CI, 1.36 to 1.74; P < .001), nosocomial pneumoni...Continue Reading

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