"(Not) all (dead) things share the same breath": identification of cell death mechanisms in anticancer therapy

Cancer Research
Santiago Rello-VaronaOscar M Tirado

Abstract

During the last decades, the knowledge of cell death mechanisms involved in anticancer therapy has grown exponentially. However, in many studies, cell death is still described in an incomplete manner. The frequent use of indirect proliferation assays, unspecific probes, or bulk analyses leads too often to misunderstandings regarding cell death events. There is a trend to focus on molecular or genetic regulations of cell demise without a proper characterization of the phenotype that is the object of this study. Sometimes, cancer researchers can feel overwhelmed or confused when faced with such a corpus of detailed insights, nomenclature rules, and debates about the accuracy of a particular probe or assay. On the basis of the information available, we propose a simple guide to distinguish forms of cell death in experimental settings using cancer cell lines.

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Citations

Nov 28, 2015·Current Problems in Cancer·G Daniel GrassSungjune Kim
Apr 24, 2015·Frontiers in Oncology·Santiago Rello-VaronaOscar Martínez Tirado
May 5, 2017·Journal of Cell Death·Benoite MéryNicolas Magné
Oct 13, 2017·Journal of Cellular Physiology·Francesco P FiorentinoIrene Marchesi
Mar 9, 2019·Scientific Reports·Santi Rello-VaronaXavier García Del Muro
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Aug 20, 2015·Cancer Research·J Martin BrownDavid G Kirsch
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Feb 14, 2018·ACS Applied Materials & Interfaces·Jian LiYan-Qing Guan

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