Not All Predictions Are Equal: "What" and "When" Predictions Modulate Activity in Auditory Cortex through Different Mechanisms

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ryszard AuksztulewiczLucia Melloni

Abstract

Using predictions based on environmental regularities is fundamental for adaptive behavior. While it is widely accepted that predictions across different stimulus attributes (e.g., time and content) facilitate sensory processing, it is unknown whether predictions across these attributes rely on the same neural mechanism. Here, to elucidate the neural mechanisms of predictions, we combine invasive electrophysiological recordings (human electrocorticography in 4 females and 2 males) with computational modeling while manipulating predictions about content ("what") and time ("when"). We found that "when" predictions increased evoked activity over motor and prefrontal regions both at early (∼180 ms) and late (430-450 ms) latencies. "What" predictability, however, increased evoked activity only over prefrontal areas late in time (420-460 ms). Beyond these dissociable influences, we found that "what" and "when" predictability interactively modulated the amplitude of early (165 ms) evoked responses in the superior temporal gyrus. We modeled the observed neural responses using biophysically realistic neural mass models, to better understand whether "what" and "when" predictions tap into similar or different neurophysiological mechanisms...Continue Reading

Citations

Apr 6, 2019·Journal of Vision·Amit Regev KrugwasserRoy Salomon
Jul 30, 2019·Acta Psychiatrica Scandinavica·H F NilesA R Powers
Jan 1, 2020·The European Journal of Neuroscience·David R Quiroga-MartinezPeter Vuust
Mar 10, 2020·Annals of the New York Academy of Sciences·Kevin S WalshRedmond G O'Connell
Jun 20, 2020·PLoS Biology·Catalina Valdés-BaizabalManuel S Malmierca
Feb 28, 2020·Nature Communications·Arnaud ZaltaBenjamin Morillon
Jul 11, 2020·The Behavioral and Brain Sciences·Martina G Vilas, Lucia Melloni
Sep 12, 2020·Journal of Neural Engineering·Elizabeth L JohnsonRobert T Knight
Feb 19, 2021·Frontiers in Human Neuroscience·HyunJung AnJan W H Schnupp
Jun 11, 2021·NeuroImage·Esra AlArno Villringer
Apr 13, 2019·NeuroImage·Gabor StefanicsJakob Heinzle
Jul 21, 2021·Journal of Vision·Christoph Huber-HuberDavid Melcher

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