Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence

Addiction Biology
Vernon Garcia-Rivas, Véronique Deroche-Gamonet

Abstract

Tobacco use leads to 6 million deaths every year due to severe long-lasting diseases. The main component of tobacco, nicotine, is recognized as one of the most addictive drugs, making smoking cessation difficult, even when 70 percent of smokers wish to do so. Clinical and preclinical studies have demonstrated consistently that nicotine seeking is a complex behavior involving various psychopharmacological mechanisms. Evidence supports that the population of smokers is heterogeneous, particularly as regards the breadth of motives that determine the urge to smoke. Here, we review converging psychological, genetic and neurobiological data from clinical and preclinical studies supporting that the mechanisms controlling nicotine seeking may vary from individual to individual. It appears timely that basic neuroscience integrates this heterogeneity to refine our understanding of the neurobiology of nicotine seeking, as tremendous progress has been made in modeling the various psychopharmacological mechanisms driving nicotine seeking in rodents. For a better understanding of the mechanisms that drive nicotine seeking, we emphasize the need for individual-based research strategies in which nicotine seeking, and eventually treatment effic...Continue Reading

References

Jan 1, 1977·Addictive Behaviors·G R Norton, B Barske
Jan 1, 1992·Psychopharmacology·E D Levin
Nov 1, 1992·Addictive Behaviors·R NiauraD J Rohsenow
Mar 1, 1992·The Medical Clinics of North America·N L Benowitz
Mar 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·D M Warburton
Jan 1, 1988·Psychopharmacology·N E GrunbergS E Winders
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·D J BowenN E Grunberg
Sep 1, 1994·Addictive Behaviors·J D KasselM Zettler-Segal
Jan 1, 1994·BMJ : British Medical Journal·J L TangN Wald
May 1, 1997·Pharmacology, Biochemistry, and Behavior·J GrossM L Stitzer
Aug 5, 1998·Health Education & Behavior : the Official Publication of the Society for Public Health Education·M C WillemsenR Genders
Dec 22, 1999·Tobacco Control·S J PhilpotK Jamrozik
Jul 18, 2000·American Journal of Public Health·N Breslau, E O Johnson
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·W B PickworthJ E Henningfield
Aug 25, 2001·Experimental and Clinical Psychopharmacology·J M Wertz, M A Sayette
Oct 30, 2001·Journal of Consulting and Clinical Psychology·C A PattenT D Wolter
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·A R CaggiulaA F Sved
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marie-France PoirierDominique Attar-Lévy
Nov 6, 2002·Psychopharmacology·Jesse DalleryMaxine L Stitzer
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-François EtterThomas V Perneger
Sep 30, 2003·The American Journal of Psychiatry·Lennart Heimer
May 18, 2004·Nature Neuroscience·Hui Zhang, David Sulzer
May 18, 2004·Nature Neuroscience·Margaret E Rice, Stephanie J Cragg
Jun 19, 2004·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Saul ShiffmanMary Hickcox
Aug 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline CohenPhilippe Soubrié
Aug 11, 2004·Journal of Consulting and Clinical Psychology·Antonio Cepeda-BenitoStephen Erath
Aug 18, 2004·Science·Véronique Deroche-GamonetPier Vincenzo Piazza
Dec 8, 2004·Molecular Psychiatry·N Hiroi, S Agatsuma
Jan 26, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christiane M ThielGereon R Fink
Feb 25, 2005·Behavioral Neuroscience·Christopher M ButtJerry A Stitzel
Mar 1, 2005·Pharmacological Reviews·Janne HukkanenNeal L Benowitz
Jun 14, 2005·Addictive Behaviors·Theodore W GardnerMichael I Posner
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karine GuillemLuis Stinus
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J Kenny, Athina Markou

❮ Previous
Next ❯

Citations

Jun 20, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michael Le GrandeGeoffrey T Fong
Aug 6, 2019·Frontiers in Behavioral Neuroscience·Vernon Garcia-RivasVéronique Deroche-Gamonet
Jun 27, 2021·Scientific Reports·Yolaine RabatSylvie Berthoz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
L H BrauerJ E Rose
Italian Heart Journal : Official Journal of the Italian Federation of Cardiology
C Chiamulera
Psychopharmacology
J E Henningfield, S J Heishman
© 2022 Meta ULC. All rights reserved