Not all that glitters is gold: A guide to critical appraisal of animal drug trials in epilepsy

Epilepsia Open
Aristea S Galanopoulou, Wenzhu B Mowrey

Abstract

Preclinical studies have produced numerous drugs with antiseizure properties which currently are the standard of care in clinical care. A third of the human population with epilepsy still continues having seizures despite the ongoing discoveries. The recognized clinical gaps of care that need to be addressed are the identification of antiepileptogenic and disease modifying treatments, treatments for refractory seizures or for seizures and epilepsies with limited or unsatisfactory treatments, such as early life epileptic encephalopathies. In this invited review, we provide a historical summary of the international efforts to re-evaluate the strategies adopted in preclinical epilepsy therapy discovery studies. We discuss issues that may impact the quality, interpretation and validation of preclinical studies and their translation to successful therapies for humans affected with epilepsy. These include the selection of animal models and the study design, research practices that affect rigor, such as appropriate use of statistics and reporting of study methods and results, their validation across models, labs and preclinical-clinical studies, the need to harmonize research methods and outcome assessment, and the importance to impro...Continue Reading

References

May 21, 1998·Epilepsia·R GuerriniP Genton
Jul 20, 2001·Epilepsy Research·J A French
Nov 9, 2002·Epilepsia·Irene A W KotsopoulosJ André Knottnerus
Aug 3, 2005·PLoS Medicine·John P A Ioannidis
Oct 18, 2005·Nature Medicine·Volodymyr I DzhalaKevin J Staley
Jan 13, 2006·Brain : a Journal of Neurology·Matti Sillanpää, Dieter Schmidt
Mar 14, 2008·Epilepsy & Behavior : E&B·Henry HassonSolomon L Moshé
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing ZhouLuis F Parada
May 30, 2009·Annals of Neurology·Jacqueline A French
Dec 1, 2009·Neurobiology of Disease·Morris H ScantleburySolomon L Moshé
Jul 9, 2010·Epilepsia·John M PellockJames W Wheless
Apr 29, 2011·Developmental Medicine and Child Neurology·Catherine Chiron
Apr 21, 2011·Neurobiology of Disease·Emmanuel RaffoAristea S Galanopoulou
Jul 21, 2011·Epilepsia·Tomonori OnoAristea S Galanopoulou
Feb 2, 2012·Epilepsia·Aristea S GalanopoulouUNKNOWN American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendat
Apr 14, 2012·Brain : a Journal of Neurology·Matti Sillanpää, Dieter Schmidt
Sep 28, 2012·Frontiers in Neurology·Christopher Andreas Turski, Chrysanthy Ikonomidou
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
Jun 7, 2013·Expert Review of Neurotherapeutics·Michael Wong
Jul 4, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
Aug 9, 2013·Epilepsia·Aristea S GalanopoulouTerence J O'Brien
Aug 9, 2013·Epilepsia·Jacqueline A FrenchEmilio Perucca
Aug 9, 2013·Epilepsia·Karen S WilcoxMichael A Rogawski
Aug 9, 2013·Epilepsia·Asla PitkänenDieter Schmidt
Aug 9, 2013·Epilepsia·Jerome EngelAnnamaria Vezzani
Sep 5, 2013·Nature Communications·Scott C BarabanGabriela A Hortopan
Sep 21, 2013·Nature Reviews. Drug Discovery·Wolfgang LöscherDieter Schmidt

❮ Previous
Next ❯

Software Mentioned

ETSP
TASK4

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Epilepsia
Aristea S GalanopoulouAmerican Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendat
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Dieter SchmidtMarc A Dichter
© 2022 Meta ULC. All rights reserved