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Not so different after all: a comparison of methods for detecting amino acid sites under selection

Molecular Biology and Evolution

May 1, 2005

Sergei L Kosakovsky Pond, Simon D.W. Frost

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Abstract

We consider three approaches for estimating the rates of nonsynonymous and synonymous changes at each site in a sequence alignment in order to identify sites under positive or negative selection: (1) a suite of fast likelihood-based "counting methods" that employ either a single most li...read more

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  • Not so different after all: a comparison of methods for detecting amino acid sites under selection

    Molecular Biology and Evolution

    May 1, 2005

    Sergei L Kosakovsky Pond, Simon D.W. Frost

    PMID: 15703242

    DOI: 10.1093/molbev/msi105

    Abstract

    We consider three approaches for estimating the rates of nonsynonymous and synonymous changes at each site in a sequence alignment in order to identify sites under positive or negative selection: (1) a suite of fast likelihood-based "counting methods" that employ either a single most li...read more

    780
    1
    Paper Details
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    • Citations770

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    • Citations770
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