Notable Aspects of Glycan-Protein Interactions

Biomolecules
Miriam Cohen

Abstract

This mini review highlights several interesting aspects of glycan-mediated interactions that are common between cells, bacteria, and viruses. Glycans are ubiquitously found on all living cells, and in the extracellular milieu of multicellular organisms. They are known to mediate initial binding and recognition events of both immune cells and pathogens with their target cells or tissues. The host target tissues are hidden under a layer of secreted glycosylated decoy targets. In addition, pathogens can utilize and display host glycans to prevent identification as foreign by the host's immune system (molecular mimicry). Both the host and pathogens continually evolve. The host evolves to prevent infection and the pathogens evolve to evade host defenses. Many pathogens express both glycan-binding proteins and glycosidases. Interestingly, these proteins are often located at the tip of elongated protrusions in bacteria, or in the leading edge of the cell. Glycan-protein interactions have low affinity and, as a result, multivalent interactions are often required to achieve biologically relevant binding. These enable dynamic forms of adhesion mechanisms, reviewed here, and include rolling (cells), stick and roll (bacteria) or surfacing ...Continue Reading

References

Jul 1, 1992·The Journal of Cell Biology·K L MooreR P McEver
Jan 1, 1989·Proteins·G M Air, W G Laver
May 1, 1994·Fertility and Sterility·B S KornovskiE Turley
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Varki
Feb 1, 1995·The Journal of Cell Biology·K L MooreR P McEver
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y LinP Primakoff
Aug 2, 1996·The Journal of Biological Chemistry·P P WilkinsR D Cummings
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·A R FoxwellA W Cripps
Jun 25, 1998·Leukemia & Lymphoma·K L Moore
Nov 26, 1998·The Journal of Biological Chemistry·P MehtaR P McEver
Apr 28, 1999·Trends in Microbiology·S UgoliniQ J Sattentau
Mar 31, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M Bernstein, M Reddy
Nov 29, 2001·The Journal of Cell Biology·I MarkovicL V Chernomordik
Dec 18, 2001·Molecular Reproduction and Development·C A VinesJ W Overstreet
Jun 20, 2002·Journal of Virology·Simon J WalkerStephen Devereux
Jun 29, 2002·Trends in Microbiology·Eric Vimr, Carol Lichtensteiger
Nov 6, 2002·Journal of Molecular Biology·Erik HahnShirley A Müller
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Melike LakadamyaliXiaowei Zhuang
Aug 28, 2003·The EMBO Journal·Billy TsaiTom A Rapoport
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Sep 25, 2004·Molecular Microbiology·Wendy E ThomasViola Vogel
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Yasuo Suzuki
Mar 12, 2005·Cellular Microbiology·Alessandra CambiCarl G Figdor
Jul 20, 2005·The Journal of Cell Biology·Maik J LehmannWalther Mothes
Oct 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Helge EwersAri Helenius
Oct 22, 2005·Nature Immunology·Rodger P McEver
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ekyune KimTadashi Baba
Feb 4, 2006·American Journal of Respiratory Cell and Molecular Biology·Judith A VoynowMary C Rose
Apr 6, 2006·Cellular and Molecular Life Sciences : CMLS·F LehmannJ Tiralongo
Apr 21, 2006·Glycoconjugate Journal·Franca Serafini-CessiDaniela Cavallone
Dec 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Audray HarrisAlasdair C Steven
Jan 24, 2007·Glycobiology·Joseph R Bishop, Pascal Gagneux

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Citations

Apr 18, 2016·Molecular Aspects of Medicine·Ian LokeMorten Thaysen-Andersen
Oct 28, 2016·PLoS Pathogens·Sheree YauNigel Grimsley
Jun 21, 2017·Molecular & Cellular Proteomics : MCP·Ian LokeMorten Thaysen-Andersen
Nov 16, 2017·Physiological Research·P Sprovieri, G Martino
Apr 29, 2020·Expert Opinion on Therapeutic Targets·Thandeka MoyoPenny L Moore
Jun 3, 2020·Nature Communications·Daniel RodererStefan Raunser
Nov 16, 2018·Parasites & Vectors·Pavlina VechtovaLibor Grubhoffer
Oct 21, 2019·Trends in Microbiology·Erik de VriesCornelis A M de Haan
Mar 7, 2021·Vaccines·Gregory S Lambert, Chitra Upadhyay
May 25, 2021·Biochemical and Biophysical Research Communications·Yu-Xi LinJung-Mao Hsu
Jan 27, 2019·The Journal of Organic Chemistry·Guangyun YuRoland J Pieters

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Methods Mentioned

BETA
glycosylation

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