Jun 1, 2011

Notch and basal cells take center stage during airway epithelial regeneration

Cell Stem Cell
Jeffrey A Whitsett, Vladimir V Kalinichenko

Abstract

Airway epithelium is maintained by basal cells, but the mechanisms responsible for repair are poorly characterized. In this issue of Cell Stem Cell, Rock et al. (2011) show that Notch signals regulate differentiation, but not self-renewal of basal cells after injury, and that this role appears conserved in mouse and human lung.

  • References8
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References

Mentioned in this Paper

Biochemical Pathway
Acropectoral Syndrome
Lung
Notch
Squamous Transitional Epithelial Cell Count
Alveolar
Epithelium
Structure of Respiratory Epithelium
Entire Respiratory Epithelium
Carcinoma of Lung

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