Notch and its oncogenic activity in human malignancies

European Surgery : ACA : Acta Chirurgica Austriaca
Marlena Brzozowa-ZasadaRomuald Wojnicz

Abstract

Increasing evidence has demonstrated that Notch signaling is deregulated in human hematological malignancies and solid tumors. This signaling has a protumorigenic effect but may also act as a tumor suppressor. How induction of a single pathway gives rise to the opposite effects in different cell types is still unknown. This review article includes available data from peer-reviewed publications associated with the role of Notch signaling during cancer pathogenesis. Numerous reports have indicated that alterations in Notch signaling and its oncogenic activity were originally associated with the pathogenesis of T‑cell acute lymphoblastic leukemia/lymphoma (T-ALL), an aggressive hematologic tumor affecting children and adolescents. The possibility that Notch could play a significant role in human breast cancer development comes from studies on mouse mammary tumor virus-induced cancer. Numerous findings over the past several years have indicated that alterations in Notch signaling are also responsible for ovarian cancer development. Mention should also be made of the connection between expression of Notch 3 and increased resistance to chemotherapy, which remains a major obstacle to successful treatment. Notch as an oncogenic factor ...Continue Reading

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Methods Mentioned

BETA
xenografts
transfection
metylotransferase
nucleotide exchange

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