Notch, BMP and WNT/β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm

Atherosclerosis. Supplements
Aleksandra KostinaAnna Malashicheva

Abstract

Cellular and molecular mechanisms of thoracic aortic aneurysm are still not clear and therapeutic approaches are mostly absent. The role of endothelial cells in aortic wall integrity is emerging from recent studies. Although Notch pathway ensures endothelial development and integrity, and NOTCH1 mutations have been associated with thoracic aortic aneurysms, the role of this pathway in aneurysm remains elusive. The purpose of the present work was to study functions of Notch genes in endothelial cells of patients with sporadic thoracic aortic aneurysm. Aortic endothelial cells were isolated from aortic tissue of patients with thoracic aortic aneurysm and healthy donors. Gene expression of Notch and related BMP and WNT/β-catenin pathways was estimated by qPCR; WNT/β-catenin signaling was studied by TCF-luciferase reporter. To study the stress-response the cells were subjected to laminar shear stress and the expression of corresponding genes was estimated by qPCR. Analyses of mRNA expression of Notch genes, Notch target genes and Notch related pathways showed that endothelial cells of aneurysm patients have dysregulated Notch/BMP/WNT pathways compared to donor cells. Activity of Wnt pathway was significantly elevated in endothelial...Continue Reading

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Citations

Jul 16, 2019·Expert Opinion on Therapeutic Targets·Giorgio AquilaAnna Malaschicheva
Nov 7, 2019·Journal of Cardiovascular Development and Disease·A IJpmaI van der Pluijm
Jul 19, 2019·Experimental and Therapeutic Medicine·Chunhua ZhangXiaoqian Hou
Dec 12, 2020·Critical Reviews in Oncology/hematology·Hussein SabitManel Esteller
Jan 31, 2021·Genes·Tyler J CreamerElena Gallo MacFarlane
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Anna MalashichevaVladimir Uspensky
Jul 16, 2021·American Journal of Human Genetics·Tanmoy RoychowdhuryCristen J Willer
Sep 9, 2020·Bioorganic & Medicinal Chemistry Letters·Yang HeGuang-Bin He

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