Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62

Microbes and Infection
Marie ChaussepiedG Langsley

Abstract

Theileria parva-infected B cells express Jagged-1 and activate Notch signalling in a parasite-dependent manner. ES-62, a filarial nematode-secreted phosphorylcholine-containing glycoprotein, is able to further stimulate Notch-mediated signalling in parasitized cells. Notch is also activated to a similar extent by addition of exogenous IL-10, and this occurs prior to any increase in proliferation in T. parva-infected B cells.

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Citations

Nov 13, 2008·International Journal for Parasitology·Carsten G K LüderVolker T Heussler
Dec 19, 2018·Frontiers in Microbiology·Shuaiyang ZhaoJianxun Luo
Feb 11, 2021·Molecular Microbiology·Shahin TajeriGordon Langsley

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