PMID: 16525728Mar 10, 2006Paper

Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells

International Journal of Molecular Medicine
Masuko Katoh, Masaru Katoh

Abstract

WNT, Notch, FGF, and Hedgehog signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Association of Notch ligands with Notch receptors on neighboring cells leads to cleavage of Notch receptors by metalloprotease and gamma-secretase to induce nuclear translocation of Notch intracellular domain (NICD). Nuclear complex, consisting of CSL (RBPSUH), NICD, Mastermind (MAML), p300 and histone acetyltransferase (HAT), then induces transcriptional activation of Notch target genes, such as HES1, HES5, HES7, HEY1, HEY2 and HEYL. Here, we searched for TCF/LEF-binding site within the promoter region of Notch ligand genes, including DLL1, DLL3, DLL4, JAG1 and JAG2. Because TCF/LEF-binding sites were identified within human JAG1 promoter based on bioinformatics and human intelligence, comparative genomics analyses on JAG1 orthologs were further performed. Chimpanzee JAG1 gene, consisting of 26 exons, was identified within NW_120319.1 genome sequence. XM_525264.1 and XM_514517.1 were not the correct coding sequences for chimpanzee JAG1. Chimpanzee JAG1 gene was found to encode a 1218-amino-acid protein showing 99.5% and 96.2% total-amino-acid identity with human JAG1 and mouse Jag1, respectively. Phy...Continue Reading

Citations

Nov 9, 2007·Breast Cancer Research and Treatment·Michael ReedijkIrene L Andrulis
Mar 2, 2011·Journal of Molecular Neuroscience : MN·Alejandra Johana CardozoPablo Francisco Argibay
Aug 16, 2008·International Journal of Colorectal Disease·Liang QiaoBenjamin C Y Wong
Nov 24, 2006·Annals of Surgical Oncology·S M LagardeJ J B van Lanschot
Jun 10, 2015·International Journal of Molecular Sciences·Luis Steven Servín-GonzálezJesús Adrián López
May 2, 2012·Cancer Letters·Neil Ashley
Apr 9, 2011·Experimental Cell Research·Michael BordonaroDarina L Lazarova
Feb 26, 2011·Gastroenterology·Blair B Madison, Hiroshi Nakagawa
Nov 16, 2010·Brain, Behavior, and Immunity·Sarah C StarossomSamia J Khoury
Nov 9, 2007·The Journal of Investigative Dermatology·Joan C SmithShirley B Russell
Nov 15, 2008·Progress in Neurobiology·Shu WenJia Liu
Jan 25, 2007·Neurosurgery Clinics of North America·Daniel A LimArturo Alvarez-Buylla
Oct 17, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Magdalena ŻakWilko Grolman
Jan 8, 2009·Journal of Cellular Biochemistry·Yan Chen, Benjamin A Alman
Nov 1, 2014·Thoracic Cancer·Huajiao GuoJian Zhang
May 29, 2013·Stem Cells·Moumita GhoshSusan D Reynolds
Nov 5, 2014·Developmental Neurobiology·Jelena PetrovicFernando Giraldez
May 24, 2012·Biochemical and Biophysical Research Communications·S Duygu SelcukluCharles Spillane
Jun 2, 2009·Developmental Biology·Senthil S SaravanamuthuPeggy S Zelenka
Sep 8, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hee-Young WonGu Kong
Sep 28, 2017·Oncotarget·Hideyuki IshiguroShuji Takiguchi

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