Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster

Developmental Biology
F BernardA Lalouette

Abstract

Drosophila dorsal longitudinal muscles develop during metamorphosis by fusion of myoblasts with larval templates. It has been shown that both vestigial and Notch are crucial for correct formation of these muscles. We investigated the relationship between vestigial and the Notch pathway during this process. Using Enhancer of Split Region Transcript m6 gene expression as a reporter of Notch pathway activity, we were able to demonstrate that this pathway is only active in myoblasts. Moreover, close examination of the cellular location of several of the main actors of the N pathway (Notch, Delta, neuralized, Serrate, Mind bomb1 and fringe) during dorsal longitudinal muscle development enabled us to find that Notch receptor can play multiple roles in adult myogenesis. We report that the locations of the two Notch ligands (Delta and Serrate) are different. Interestingly, we found that fringe, which encodes a glycosyltransferase that modifies the affinity of the Notch receptor for its ligands, is expressed in muscle fibers and in a subset of myoblasts. In addition, we demonstrate that fringe expression is essential for Notch pathway inhibition and muscle differentiation. Lastly, we report that, in vestigial mutants, fringe expression ...Continue Reading

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Citations

Aug 6, 2010·Molecular Biology of the Cell·Hua DengAndrew J Simmonds
Dec 30, 2006·Gene Expression Patterns : GEP·Norbert K HessSanford I Bernstein
Oct 16, 2015·The Journal of Cell Biology·Nagaraju DhanyasiEyal D Schejter
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Apr 11, 2020·Current Biology : CB·Hadi BoukhatmiSarah Bray
Aug 28, 2021·BMC Developmental Biology·Antonio Celestino-MontesFidel de la Cruz Hernández-Hernández
Jan 30, 2009·Science Signaling·Alena KrejcíSarah J Bray

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