Notch receptor encodes two structurally separable functions in Drosophila: a genetic analysis

Developmental Dynamics : an Official Publication of the American Association of Anatomists
T LangdonAlfonso Martinez Arias

Abstract

The Notch gene of Drosophila encodes a single transmembrane receptor that plays a central role in the process of lateral inhibition. This process results in the selection of individual mesodermal and neural precursors during the development of the muscular and nervous systems. The activation of Notch during lateral inhibition is mediated by the transmembrane ligand Delta (Dl) and effected by the transcription factor Suppressor of Hairless (Su(H)). The same functional cassette plays a role in other processes, in particular, the development and patterning of the wing. Genetic analysis has suggested that, in addition to the Su(H)-dependent pathway, Notch can signal in an Su(H)-independent manner. This process seems to be tightly associated with signalling by Wingless, a member of the Wnt family of signalling molecules. Here, we have analyzed further the possibility that the Notch protein encodes two different functions. To do so, we have studied the activities and genetic properties of different Notch receptors bearing deletions of specific regions of the intracellular and the extracellular domains in different developmental processes, and have sought to correlate the activity of these mutant proteins with those of existing mutant...Continue Reading

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Citations

Jan 23, 2008·BMC Developmental Biology·Zifei Pei, Nicholas E Baker
Aug 12, 2009·PLoS Biology·Phil G T SandersAlfonso Martinez Arias
Jan 5, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Silvia Muñoz-DescalzoAlfonso Martinez Arias
Jan 19, 2010·Developmental Biology·Diego R RevinskiSilvia L López
Nov 9, 2010·Mechanisms of Development·David D O'KeefeLeslie J Saucedo
Mar 17, 2010·The Biochemical Journal·Jaswinder K Sethi, Antonio Vidal-Puig
Feb 14, 2012·Seminars in Cell & Developmental Biology·Silvia Muñoz Descalzo, Alfonso Martinez Arias
Aug 19, 2007·Molecular and Cellular Neurosciences·Hyung-Kook Lee, Martha J Lundell
Dec 9, 2008·Circulation Research·David MorrowPaul A Cahill
Aug 1, 2007·The Journal of Biological Chemistry·Philip S HodkinsonTariq Sethi
Feb 15, 2007·Genesis : the Journal of Genetics and Development·Stacy L K RasmussenNicholas D Holland
Jan 15, 2008·Development·Penelope HaywardAlfonso Martinez Arias

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