Notch signaling and non-small cell lung cancer

Oncology Letters
Bin ZouJi-Chun Liu

Abstract

Lung cancer is the leading cause of cancer-associated mortality worldwide. Elucidation of the pathogenesis and biology of lung cancer is critical for the design of an effective treatment for patients. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. The abnormal expression of Notch signaling pathway members is a relatively frequent event in NSCLC. The Notch signaling pathway serves important roles in cell fate determination, proliferation, differentiation and apoptosis. Increasing evidence supports the association of Notch signaling dysregulation with various types of malignant tumor, including NSCLC. Several studies have demonstrated that members of the Notch signaling pathway may be potential biomarkers for predicting the progression and prognosis of patients with NSCLC. Furthermore, Notch signaling serves critical roles in the tumorigenesis and treatment resistance of NSCLC cells by promoting the proliferation or inhibiting the apoptosis of NSCLC cells. The present review provides a detailed summary of the roles of Notch signaling in NSCLC.

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Citations

Aug 25, 2019·Journal of Clinical Medicine·Claudia von ArxSalvatore Tafuto
Feb 2, 2019·International Journal of Molecular Sciences·Beatriz BallesterJulio Cortijo
Aug 14, 2020·International Journal of Molecular Sciences·Amnah SharifRodrigo Fernandez-Valdivia
Apr 4, 2021·International Journal of Molecular Sciences·Sara LettieriGiulia Maria Stella
Oct 12, 2021·Medical Oncology·Kumud Nigam, Ratnesh Kumar Srivastav

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xenografts
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