Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology

Journal of Cancer Research and Clinical Oncology
Gang DengZhijian Yu

Abstract

This review aims to summarize the evidence that Notch signaling is associated with prostate development, tumorigenesis and prostate tumor progression. Studies in PubMed database were searched using the keywords of Notch signaling, prostate development and prostate cancer. Relevant literatures were identified and summarized. The Notch pathway plays an important role in determining cell fate, proliferation, differentiation and apoptosis. Recent findings have highlighted the involvement of Notch signaling in prostate development and in the maintenance of adult prostate homeostasis. Aberrant Notch expression in tissues leads to dysregulation of Notch functions and promotes various neoplasms, including prostate cancer. High expression of Notch has been implicated in prostate cancer, and its expression increases with higher cancer grade. However, the precise role of Notch in prostate cancer has yet to be clearly defined. The roles of Notch either as an oncogene or tumor suppressor in prostate cancer hallmarks such as cell proliferation, apoptosis and anoikis, hypoxia, migration and invasion, angiogenesis as well as the correlation with metastasis are therefore discussed. Notch signaling is a complicated signaling pathway in modulatin...Continue Reading

References

Jul 1, 1997·Nature Genetics·T OdaS C Chandrasekharappa
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·R E ReiterO N Witte
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·F LogeatA Israël
Jan 27, 1999·Seminars in Cell & Developmental Biology·R J Fleming
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Oct 6, 2000·Genes & Development·C Abate-Shen, M M Shen
Dec 9, 2000·Developmental Biology·J S Mumm, R Kopan
Jan 11, 2001·Developmental Biology·G BushG Weinmaster
Jun 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·E M ValveP L Härkönen
Jan 5, 2002·Differentiation; Research in Biological Diversity·Y WangG Cunha
Jun 7, 2002·Mechanisms of Development·Simon Kidd, Toby Lieber
Jun 8, 2002·Annual Review of Neuroscience·Nicholas Gaiano, Gord Fishell
Jun 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward P Gelmann
Dec 21, 2002·Differentiation; Research in Biological Diversity·Gerald R CunhaY Z Wang
Dec 24, 2002·Cancer Biology & Therapy·Eric J AllenspachWarren S Pear
Jan 28, 2003·Journal of Cellular Physiology·Tatsuya IsoYasuo Hamamori
Jan 28, 2003·Cancer·Carlton R CooperKenneth J Pienta
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Mar 21, 2003·Developmental Biology·Paul C MarkerGerald R Cunha
Aug 28, 2003·Developmental Biology·Annemarie A DonjacourGerald R Cunha
Dec 4, 2003·Developmental Biology·Sarah H FreestoneAxel A Thomson
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·L Charles MurtaughDouglas A Melton
Mar 12, 2004·Developmental Biology·David M BermanMichael M Shen
Jul 28, 2004·Biochemistry·Patrick C FraeringMichael S Wolfe
Aug 27, 2004·Nature·Lance A Liotta, Elise Kohn
Oct 7, 2004·Cancer Research·Sandro SantagataJon C Aster
Nov 13, 2004·The Journal of Pathology·R HeerH Y Leung
Jan 18, 2005·Experimental Cell Research·Victoriano BaladrónJorge Laborda
Feb 3, 2005·Molecular and Cellular Biology·Borja BelandiaMalcolm G Parker

❮ Previous
Next ❯

Citations

Apr 28, 2017·Journal of Cell Science·Sander B FrankCindy K Miranti
Oct 3, 2017·PLoS Pathogens·Laura V GlaserBettina Kempkes
Dec 17, 2016·Oncotarget·Alice FaversaniSilvano Bosari
Jul 7, 2017·Journal of Gastrointestinal Cancer·GholamReza Karami MadaniMohammad Mahdi Forghanifard
Jun 14, 2017·Molecular Cancer Research : MCR·Ahmed A MohamedShiv Srivastava
Mar 31, 2019·Differentiation; Research in Biological Diversity·Joseph AldahlZijie Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

Differentiation; Research in Biological Diversity
Kevin G Leong, Wei-Qiang Gao
Trends in Molecular Medicine
Jacqueline L Avila, Joseph L Kissil
Cellular and Molecular Life Sciences : CMLS
U Koch, Freddy Radtke
© 2022 Meta ULC. All rights reserved