Notch Signaling in the Tumor Microenvironment

Cancer Cell
Olivier Meurette, Patrick Mehlen

Abstract

The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. However, it is now clear that cancer progression and metastasis depend on the bidirectional interactions between cancer cells and their environment, forming the tumor microenvironment (TME). These interactions are mediated and constantly evolve through paracrine and juxtacrine signaling. In this review, we discuss how Notch signaling takes an important part in regulating the crosstalk between the different compartments of the TME. We also address the consequences of the Notch-TME involvement from a therapeutic perspective.

Citations

Mar 16, 2019·International Journal of Cancer. Journal International Du Cancer·Ziqian LiJun Du
Feb 6, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takuya OmoteharaMasahiro Itoh
Jul 16, 2019·Cancer Cell International·Elsa N Garza TreviñoAlejandra Martinez Garza
Jan 3, 2020·International Journal of Molecular Medicine·Masuko Katoh, Masaru Katoh
Jul 18, 2020·Nutrition and Cancer·Nilesh Kumar SharmaJayanta K Pal
May 23, 2019·British Journal of Cancer·Odd Terje Brustugun
Feb 13, 2020·Signal Transduction and Targeted Therapy·Liqun YangHongjuan Cui
Sep 29, 2020·Frontiers in Oncology·Asunción Espinosa-SánchezAmancio Carnero
Sep 13, 2020·Non-coding RNA·Lavinia RaimondiNicola Amodio
Dec 6, 2018·Frontiers in Oncology·Erik W J MollenMarc A G G Vooijs
Mar 22, 2019·Cancers·Karl KunzelmannRainer Schreiber
Jun 19, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Colm J O'RourkeJesper B Andersen
May 10, 2020·Cells·Madalena C PintoKarl Kunzelmann
Apr 30, 2020·Frontiers in Immunology·Paola GrazioliAntonio Francesco Campese
Aug 25, 2020·Journal of Cellular and Molecular Medicine·Varun Chandra BoinpellySharmila Shankar
Oct 3, 2020·Cells·Luca PagliaroGiovanni Roti
Apr 21, 2019·Cancers·Elke KaemmererNikolaus Gassler
Mar 29, 2019·JBMR Plus·Emily G Atkinson, Jesús Delgado-Calle
Nov 7, 2019·Biomolecules·Malini MukherjeeKameswaran Surendran
Jan 25, 2020·Journal of Cellular and Molecular Medicine·Shao-Hua DaiXue-Liang Zhou
Dec 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Federico BocciMohit Kumar Jolly
May 16, 2019·Journal of Cellular Physiology·Sebastián BocchicchioGriselda Irusta
Oct 11, 2019·Precision Clinical Medicine·Demeng Chen, Cun-Yu Wang
Jun 12, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Mohd RihanAmit Khairnar
Oct 7, 2020·Molecular Biology Reports·Meng-Cheng LiuJamie J Newman
Oct 13, 2020·Tissue Engineering. Part B, Reviews·Kathleen Zohorsky, Kibret Mequanint
Oct 28, 2020·Journal of Cellular Physiology·Bo WangPeijun Liu
Dec 1, 2020·Clinical & Translational Immunology·Habib Sadeghi RadArutha Kulasinghe
Oct 8, 2020·ELife·Rui TangMonte M Winslow
Nov 20, 2020·The Oncologist·Marijo BilusicElizabeth Plimack

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