PMID: 16619872Apr 20, 2006Paper

Notch signaling pathway and new strategies in cancer treatment

Salud pública de México
Leticia SantosErika Nahomy Marino-Marmolejo

Abstract

The Notch signaling pathway plays a crucial role at different stages of cell development, such as proliferation, growth, differentiation, and apoptosis. Recent studies demonstrate that depending on the expression level and cellular context, the Notch receptors play a role in apoptosis resistance in malignant cells. These findings suggest that Notch signaling components may be a potential target in the development of new cancer therapies. This review describes the function of the Notch pathway and new strategies in the modulation of its signal.

Citations

Nov 15, 2013·Therapeutic Advances in Neurological Disorders·Sara Anna BoniniMaurizio Memo

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