Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells

Immunity
Keiki KumanoHisamaru Hirai

Abstract

Hematopoietic stem cells (HSCs) are thought to arise in the aorta-gonad-mesonephros (AGM) region of embryo proper, although HSC activity can be detected in yolk sac (YS) and paraaortic splanchnopleura (P-Sp) when transplanted in newborn mice. We examined the role of Notch signaling in embryonic hematopoiesis. The activity of colony-forming cells in the YS from Notch1(-/-) embryos was comparable to that of wild-type embryos. However, in vitro and in vivo definitive hematopoietic activities from YS and P-Sp were severely impaired in Notch1(-/-) embryos. The population representing hemogenic endothelial cells, however, did not decrease. In contrast, Notch2(-/-) embryos showed no hematopoietic deficiency. These data indicate that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells.

References

Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·I GodinA Cumano
Mar 15, 1994·Genes & Development·P J SwiatekT Gridley
Jan 1, 1996·Immunity·S Delassus, A Cumano
May 5, 1997·FEBS Letters·M OkabeY Nishimune
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y YamadaT H Rabbitts
Apr 7, 1998·Molecular and Cellular Biology·A BigasL A Milner
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Jun 18, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C J MarshallA J Thrasher
Nov 9, 2000·The Journal of Experimental Medicine·F N KaranuM Bhatia
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Gridley
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B K HadlandR Kopan
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·P DoerflerR M Perlmutter
Feb 14, 2002·Immunology Letters·Etsuko YamaguchiHisamaru Hirai
Mar 29, 2002·Nature Immunology·Stuart H Orkin, Leonard I Zon
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sayyed K ZaidiJane B Lian

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Citations

Mar 11, 2010·Annals of Hematology·Kun ZhouHanying Sun
Jun 16, 2012·Journal of Cardiovascular Translational Research·Gemma M Balmer, Paul R Riley
Jun 8, 2011·Leukemia·K V PajciniW S Pear
Jun 10, 2011·Nature·Wilson K ClementsDavid Traver
Feb 27, 2004·Nature Immunology·Freddy RadtkeH Robson MacDonald
Jan 25, 2005·Nature Immunology·Andrew W DuncanTannishtha Reya
Jan 22, 2008·Nature Immunology·Elaine Dzierzak, Nancy A Speck
Apr 14, 2006·Nature Reviews. Cancer·Clemens GrabherA Thomas Look
Apr 27, 2013·Nature Reviews. Immunology·Wilson K Clements, David Traver
Jun 17, 2005·Leukemia·S SakajiriH P Koeffler
Jul 18, 2012·The Journal of Experimental Medicine·Cristina Ruiz-HerguidoAnna Bigas
Apr 8, 2004·Stem Cells and Development·Malcolm A S Moore
Feb 24, 2005·Stem Cells and Development·Weiming LiMervin C Yoder
Sep 17, 2005·Genes & Development·Caroline Erter BurnsLeonard I Zon
Mar 21, 2008·Pigment Cell & Melanoma Research·Keiki KumanoShigeru Chiba
May 19, 2005·Molecular and Cellular Biology·Kazunobu TachibanaAlan Bernstein
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Volker Hartenstein
Mar 3, 2010·Annual Review of Immunology·Julie S YuanCynthia J Guidos
Mar 18, 2005·Annual Review of Immunology·Ivan MaillardWarren S Pear
Jun 8, 2011·The Journal of Clinical Investigation·Nagisa SakuraiTakahiro Maeda
Jan 25, 2007·Blood·Mrinmoy SanyalMichael L Cleary
Nov 22, 2005·International Journal of Hematology·Alexis DumortierFreddy Radtke
Nov 22, 2005·International Journal of Hematology·Takahiro Suzuki, Shigeru Chiba
Dec 8, 2011·Haematologica·Ralf Schwanbeck, Ursula Just
Jul 18, 2012·Haematologica·Bahar Mirshekar-SyahkalKatrin Ottersbach
Jan 17, 2014·Nature·Aruna KodeStavroula Kousteni
May 19, 2012·Regenerative Medicine·Thomas Clapes, Catherine Robin

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