NOTCH3 gene polymorphism is associated with the prognosis of gliomas in Chinese patients

Medicine
Zhipeng ShenQing Zhang

Abstract

Recent studies show that NOTCH3 is involved in the glioma development and it is also a prognostic factor for glioma patients. However, the gene polymorphism of NOTCH3 in gliomas prognosis remains unknown.A total of 266 patients were enrolled into this study. The NOTCH3 gene polymorphism at 3 loci, including C>T polymorphism at nucleotide 381, C>A polymorphism at 474 and G>A polymorphism at 684 were determined. All patients received the surgical treatment and/or chemotherapy and/or radiotherapy.We found that the 684G>A polymorphism affects the tumor NOTCH3 expression level and is closely associated with a higher tumor grade, poorer tumor differentiation, and karnofsky performance score in these glioma patients. More importantly, the 684G>A polymorphism is significantly associated with the prognosis of these patients regardless of their treatment manner.Our study indicates that the NOTCH3 gene 684G>A polymorphism may be used as a prognosis marker for gliomas.

References

Jun 1, 2005·Experimental Cell Research·Ryoichiro KageyamaRyosuke Ohsawa
Jun 17, 2005·Cancer Research·Ileana C CuevasAnita Lal
Jan 24, 2006·Cephalalgia : an International Journal of Headache·S SchwaagG Kuhlenbäumer
Jun 17, 2006·Cancer Research·Joon T ParkTian-Li Wang
Dec 7, 2006·Science's STKE : Signal Transduction Knowledge Environment·Matthias EhebauerAlfonso Martinez-Arias
Mar 21, 2007·Journal of Neurosurgery·Masayuki KanamoriRussell O Pieper
Jan 11, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sung Hak LeeSug Hyung Lee
May 9, 2009·Pathology Oncology Research : POR·Peng XuPeiyu Pu
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Stephen L Rose
Sep 4, 2010·Cephalalgia : an International Journal of Headache·S MenonL R Griffiths
Jan 20, 2011·Cancer Research·Tarran J PierfeliceCharles G Eberhart
Mar 10, 2012·Omics : a Journal of Integrative Biology·Mahfoud AssemTimothy C Ryken
Dec 15, 2012·Journal of Neuro-oncology·Mengjun LiYugang Jiang
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Jie LiangXue Qin

❮ Previous
Next ❯

Citations

Jun 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tieyi HuYi You
Jul 18, 2019·Annals of Surgical Oncology·Jang Hyuck LeeJae Yong Park

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
Genotyping
electrophoresis

Software Mentioned

SPSS

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Zhipeng ShenJiajie Fan
Asian Pacific Journal of Cancer Prevention : APJCP
Yao-Wu WangBao-Hua Jiao
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Liang WangYongsheng Zhang
© 2022 Meta ULC. All rights reserved