NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia

Psychiatric Genetics
Sami AnttilaEsa Leinonen

Abstract

The NOTCH4 gene has a promoter polymor-phism at position -25, which leads to the three genotypes TT, CT and CC. These have been suggested to present a novel independent genetic risk factor for schizophrenia. We conducted a prospective case-control study to explore the impact of NOTCH4 T-25C polymorphism on the factors associated with schizophrenia. NOTCH4 gene promoter T-25C polymorphism was determined by polymerase chain reaction among 94 patients with schizophrenia and 94 healthy age-matched and sex-matched blood donors. The T allele was highly associated with an earlier age of onset in male patients of schizophrenia (Kaplan-Meier log-rank test P<0.0001). Moreover, the male patients carrying the T allele were born significantly more often in June-November compared with other months of the year [odds ratio=3.92 (95% confidence interval=1.025-15.018), P=0.046]. No association was determined, however, between the NOTCH4 gene polymorphism under study and schizophrenia. The NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia and thus may be related to an early pathogenesis of schizophrenia in young patients. Alternatively, these findings may represent a significant genetic marker for managing sub...Continue Reading

References

Apr 1, 1997·The American Journal of Psychiatry·H Y MeltzerP A Thompson
Jan 15, 1998·Schizophrenia Research·E F TorreyR H Yolken
Sep 12, 1998·The American Journal of Psychiatry·B KirkpatrickE Bromet
May 29, 2000·Psychological Medicine·J M SuvisaariJ K Lönnqvist
Aug 10, 2000·Nature Genetics·J Wei, G P Hemmings
Feb 15, 2001·Archives of General Psychiatry·B KirkpatrickW T Carpenter

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Citations

Mar 5, 2013·Journal of Molecular Neuroscience : MN·Aihua YuanShunying Yu
Jan 20, 2004·Neuroscience Letters·Lin-Lin LiuGwynneth P Hemmings
Feb 28, 2004·Clinical Genetics·J A HarperC J Guidos
Jun 21, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ke-Sheng WangYue Pan
Apr 25, 2006·Schizophrenia Research·Rainald Schmidt-KastnerChristoph Schmitz
Dec 23, 2014·Journal of Molecular Neuroscience : MN·Tea TerzićBlanka Kores Plesničar
Jun 25, 2017·Neuroscience and Biobehavioral Reviews·Angela IannitelliGiuseppe Bersani
Feb 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Eileen Joyce
Apr 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elizabeth HareMichael A Escamilla
Mar 16, 2006·Psychiatric Genetics·Nobuto ShibataHeii Arai

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