Notes from the Field: Administration Error Involving a Meningococcal Conjugate Vaccine--United States, March 1, 2010-September 22, 2015

MMWR. Morbidity and Mortality Weekly Report
John R SuMaria Cano

Abstract

Menveo (GlaxoSmithKline, previously Novartis AG) is a conjugate vaccine that was recommended in October 2010 for routine use in adolescents (preferably aged 11 or 12 years, with a booster at 16 years), and among persons aged 2 through 54 years with certain immunosuppressive conditions, to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135 (1). These recommendations have since been updated (2). Menveo is supplied in two vials that must be combined before administration. The MenA lyophilized (freeze-dried) component must be reconstituted with the MenCYW-135 liquid component (Figure). To administer the vaccine, the liquid component is drawn into a syringe, and used to reconstitute the lyophilized component. The resulting solution is administered by intramuscular injection. Failure to prepare Menveo as directed by the manufacturer's instructions can lead to lack of protection against the intended pathogens (N. meningitidis serogroups A, C, Y, and/or W-135) (3). Recently, an immunization provider administered only the lyophilized component of Menveo, subsequently administered a properly prepared dose of Menveo to the same patient, and asked CDC if this practice was safe. This questi...Continue Reading

Citations

Nov 17, 2011·Vaccine·Vincent PavotStéphane Paul
Sep 22, 2017·Human Vaccines & Immunotherapeutics·Tanya R Myers, Michael M McNeil
Aug 31, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fernanda Tavares-Da-SilvaJens-Ulrich Stegmann
May 26, 2018·MMWR. Morbidity and Mortality Weekly Report·Tom T ShimabukuroMaria V Cano
Nov 6, 2020·Pharmaceutical Medicine·Farzana SamadDennis E Doherty
Aug 10, 2021·Expert Review of Vaccines·Federico Martinón-TorresPhilipp Oster

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