NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors

FEBS Letters
V KashubaL Kisselev

Abstract

By applying the 'recognition mask' strategy to 300 mammalian sequences containing NotI sites we demonstrated that 5' ends of genes are highly enriched in NotI sites. A NotI linking clone NL2-252 (D3S1678) containing transferrin receptor (TFRC) gene was used as an initial point for chromosomal jumping. One of the jumping clones, J21-045 traverses 210 kbp and links NL2-252 to NL26 (D3S1632), a NotI linking clone containing highly polymorphic sequences. The TFRC gene was mapped to 3q29, close to the telomeric marker D3S2344, by linkage analysis, a panel of hybrid cell lines, GeneBridge 4 panel and FISH. Clone NLM-007 (D3S4302) was found to contain ras-homologous gene RAB7. By FISH and a panel of hybrid cell lines this gene was mapped to 3q21. This region is of particular interest due to frequent rearrangements in different types of leukemia. Clone L2-081 (D3S4283) containing new member of ubiquitin-specific proteases (HAUSP gene) was localized in 3p21 inspiring further investigation of involvement of this gene in development of lung and renal carcinomas.

References

Aug 1, 1992·Genomics·F LarsenH Prydz
Feb 1, 1991·Human Genetics·M F Rousseau-MerckR Berger
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·S K LawrenceS M Weissman
Sep 28, 1995·Nature·R M GemmillH Wang
Jun 1, 1994·Genomics·E R ZabarovskyV I Zabarovska
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K KokB Carritt
Aug 1, 1993·Nature Genetics·H IchikawaM Ohki
Dec 1, 1995·The Journal of Cell Biology·Y FengA Wandinger-Ness
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y ZhuA D D'Andrea
Jan 1, 1996·Cytogenetics and Cell Genetics·S L NaylorL Messiaen
Sep 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A I ProtopopovE R Zabarovsky
Jan 3, 1997·The Journal of Biological Chemistry·Y ZhuA D D'Andrea
Apr 1, 1997·Nature Genetics·F MitelmanB Johansson

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Citations

Oct 19, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Donghua HeZhen Cai
May 18, 2005·Biochemical and Biophysical Research Communications·Harshawardhan P BalWayne A Marasco
Jul 3, 2013·Seminars in Cancer Biology·Séverine LorinPatrice Codogno
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A RáczE Meese
Aug 18, 2010·Antioxidants & Redox Signaling·Eugenia MorselliGuido Kroemer
Mar 10, 2000·Nucleic Acids Research·E R ZabarovskyC Wahlestedt
Jan 15, 2002·Nucleic Acids Research·Veronika I ZabarovskaEugene R Zabarovsky
Nov 20, 2001·Molecular and Cellular Biology·S G ChoZ Ronai
Mar 20, 2015·BioMed Research International·Punit PrasadKarl Ekwall
Oct 21, 2014·BioMed Research International·Yenniffer ÁvalosAndrew F G Quest
Oct 17, 1998·The Journal of Biological Chemistry·X B QiuA Dutta
Oct 16, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tonika LamZhenming Xu
Sep 25, 2003·Cell Motility and the Cytoskeleton·Wolfgang GartnerLudwig Wagner
Jul 19, 2011·Oncogene·W K K WuJ J Y Sung
Jun 23, 2001·Oncogene·L C SutherlandB A Miller
Aug 22, 2001·Biopolymers·M Bina, E Crowely
May 30, 2012·Journal of Cell Science·Emma Y Liu, Kevin M Ryan

❮ Previous
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