Notoginsenoside R1 protects boar sperm during liquid storage at 17°C.

Reproduction in Domestic Animals = Zuchthygiene
Fa RenJ-H Hu

Abstract

Reactive oxygen species (ROS) damage mammalian sperm during liquid storage. Notoginsenoside R1 (NR1) is a compound isolated from the roots of Panax notoginseng; it has powerful ROS-scavenging activities. This work hypothesized that the antioxidant capacity of NR1 could improve boar sperm quality and fertility during liquid storage. During liquid storage at 17°C, the supplementation of semen extender with NR1 (50 μM) significantly improved sperm motility, membrane integrity and acrosome integrity after 5 days of preservation. NR1 treatment also reduced ROS and lipid peroxidation (LPO) levels at day 5 (p <0.05). Higher glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) levels and sperm-zona pellucida binding capacity were observed in the 50 μM NR1 group than those in the control group at day 7 (p <0.05). Importantly, statistical analysis of the fertility of 200 sows indicated that addition of NR1 to the extender improved the fertility parameters of boar spermatozoa during liquid storage at 17°C (p <0.05). These results demonstrate the practical feasibility of using 50 μM NR1 as an antioxidant in boar extender during liquid storage at 17°C, which is beneficial to both spermatozoa quality and fertility.

References

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B K Davis
Nov 20, 2012·Animal Reproduction Science·Chunmei XiaJianhui Tian
Jun 2, 2014·Animal Reproduction Science·Noelia Prieto-MartínezMarc Yeste
Jan 26, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Xiao-Gang ZhangJian-Hong Hu
Aug 5, 2017·Porcine Health Management·Alfonso Lopez RodriguezDominiek Maes
Jun 19, 2019·Theriogenology·I ParrillaJ Roca
Mar 14, 2020·Animals : an Open Access Journal From MDPI·José Luis Ros-SantaellaEliana Pintus

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