Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases.

International Journal of Molecular Sciences
Shaobo WangBaoan Song

Abstract

Rice bacterial leaf blight and leaf streak are two important bacterial diseases of rice, which can result in yield loss. Currently, effective antimicrobials for rice bacterial diseases are still lacking. Thus, to develop highly effective and low-risk bactericides, 31 novel 1,3,4-oxadiazole derivatives containing a cinnamic acid moiety were designed and synthesized. Bioassay results demonstrated that all compounds exhibited good antibacterial activities in vitro. Significantly, compounds 5r and 5t showed excellent antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc), with the 50% effective concentration (EC50) values of 0.58 and 0.34, and 0.44 and 0.20 μg/mL, respectively. These compounds were much better than thiodiazole copper (123.10 and 161.52 μg/mL) and bismerthiazol (85.66 and 110.96 μg/mL). Moreover, compound 5t had better protective and curative activities against rice bacterial leaf blight and leaf streak than thiodiazole copper and bismerthiazol in vivo. Simultaneously, the in vivo efficacy of the compounds was demonstrated by real-time quantitative PCR to quantify bacterial titers. In addition, a three-dimensional quantitative structure⁻activity relationship model was ...Continue Reading

References

Nov 1, 1994·International Journal of Food Microbiology·P DalgaardT A McMeekin
Dec 21, 2002·The Journal of Organic Chemistry·Xini ZhangDawei Xu
Apr 17, 2009·Journal of Agricultural and Food Chemistry·Shipra VishnoiVirendra K Kasana
Dec 3, 2009·Journal of Agricultural and Food Chemistry·Zhen-Peng KaiXin-Ling Yang
Sep 1, 2006·Molecular Plant Pathology·David O Niño-LiuAdam J Bogdanove
Jan 3, 2012·Journal of Agricultural and Food Chemistry·Wei-Ming XuBao-An Song
Apr 20, 2012·Mini Reviews in Medicinal Chemistry·M Sova
Aug 31, 2012·Journal of Agricultural and Food Chemistry·Hesham R El-SeediRob Verpoorte
Oct 31, 2012·International Journal of Molecular Sciences·Jihua WangLan Wang
Jun 7, 2014·Annual Review of Phytopathology·Wende LiuGuo-Liang Wang
Mar 20, 2016·International Journal of Biological Macromolecules·Caifeng YangFuan Wu
May 18, 2017·International Journal of Molecular Sciences·Eva Heřmánková-VavříkováVladimír Křen
Aug 28, 2018·Journal of Agricultural and Food Chemistry·Jixiang ChenBaoan Song
Oct 4, 2018·International Journal of Molecular Sciences·Zhiyuan JiKaijun Zhao
Oct 12, 2018·International Journal of Molecular Sciences·Nahee BaeSang-Wook Han

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Citations

Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei WangLinhong Jin
Dec 29, 2020·Bioorganic & Medicinal Chemistry·Valentin KarabelyovViolina T Angelova
May 1, 2021·International Journal of Molecular Sciences·Antonio Palumbo Piccionello

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
SPSS17
CoMSIA
CoMFA

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