Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists

Bioorganic & Medicinal Chemistry Letters
Gavin A WhitlockRichard J Thurlow

Abstract

Novel 2-imidazoles have been identified as potent partial agonists of the alpha(1A) adrenergic receptor, with good selectivity over the alpha(1B), alpha(1D) and alpha(2A) receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.

References

Jan 1, 1981·Drug Metabolism Reviews·B Testa, P Jenner
Feb 3, 2007·Current Topics in Medicinal Chemistry·Michael J Bishop

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Citations

Apr 28, 2009·Bioorganic & Medicinal Chemistry Letters·Gavin A WhitlockAlan Stobie
May 29, 2015·Medicinal Research Reviews·Maris VilumsAdriaan P IJzerman
Sep 10, 2014·The Journal of Organic Chemistry·Cristina Pérez-CaaveiroLuis A Sarandeses
Jan 7, 2021·Journal of Chemical Information and Modeling·Katherine J SchultzRyan S Renslow

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