Novel 3D-microcarriers from recombinant spidroin for regenerative medicine

Doklady. Biochemistry and Biophysics
M M MoisenovichM P Kirpichnikov

Abstract

Microcarriers generated from recombinant spidroin 1F9 are suitable for use as an injection material. The microcarriers were a heterogeneous mixture of microgel particles ranging from 50 to 300 µm in size with the predominance of particles of 50-150 µm. The surface of these microparticles had a complex topography and ensured efficient cultivation of primary and immortalized fibroblasts. Intradermal injections of microgel suspensions into the area of full-thickness skin wounds did not lead to the development of acute inflammation in mice; instead, they accelerated the recovery of skin tissue and stimulated neurogenesis and angiogenesis.

References

Nov 19, 2010·Tissue Engineering. Part B, Reviews·Yella MartinJustin R Sharpe
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·M M MoisenovichI I Agapov
Mar 1, 2012·Biomaterials·Mikhail M MoisenovichIgor I Agapov
Jul 4, 2015·In Vitro Cellular & Developmental Biology. Animal·Hyunhee Ju, Sungho Ghil

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Citations

Mar 31, 2016·Doklady. Biochemistry and Biophysics·M M MoisenovichM P Kirpichnikov
Aug 8, 2019·Drug Development Research·Noura H Abd EllahHelal F Hetta
Apr 20, 2017·Doklady. Biochemistry and Biophysics·M M MoisenovichM P Kirpichnikov
Oct 13, 2020·Biochemistry. Biokhimii︠a︡·A M MoysenovichI A Demina
Sep 30, 2018·Advanced Drug Delivery Reviews·Austin P VeithAaron B Baker
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vladimir G Debabov, Vladimir G Bogush

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