Abstract
Candidate genes for association studies in panic disorder are often selected on the basis of molecular mechanisms of drugs utilized in challenge tests such as m-chlorophenylpiperazine (mCPP), a non-selective 5-HT2C receptor agonist. Two novel, adjacent polymorphisms [(GT)12-18 and (CT)4-5] in the 5'-regulatory region of the X-chromosomal 5-HT2C receptor gene have recently been reported. We determined the allele frequency of long vs. short polymorphism haplotypes in a German and an Italian sample (combined n = 211) of panic disorder patients (DSM-III-R) and compared it with allele frequencies in two ethnically matched control samples (combined n = 226). In the German sample, a comparison of female genotypes containing the short haplotype vs. female genotypes containing only long haplotypes showed a significant difference (p = 0.01, ?2 analysis). In the Italian sample, however, this observation could not be replicated (p = 0.54, ?2 analysis). This argues against a major role for these promoter-associated 5-HT2C receptor gene length polymorphisms in the aetiopathogenesis of panic disorder.
Citations
Jul 16, 2005·Human Genetics·Shane McCarthyBjörn Andersson
Aug 15, 2001·Neuroscience Letters·B GutiérrezL Fañanás
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K P Lesch
Apr 1, 2004·Acta Neuropsychiatrica·Dirk van West, Stephan Claes
Jul 7, 2007·Genes, Brain, and Behavior·M GratacòsM Dierssen
Mar 21, 2002·Expert Review of Molecular Diagnostics·R W KerwinM J Arranz
May 28, 2008·European Archives of Psychiatry and Clinical Neuroscience·Vincenzo De LucaJames L Kennedy
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Antonio Drago, Alessandro Serretti
Sep 24, 2015·Molecular Psychiatry·A S HoweV De Luca
Mar 5, 2004·Expert Opinion on Therapeutic Targets·Alessandro SerrettiDiana De Ronchi
Oct 12, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michele Fornaro
Aug 18, 2001·Cell Calcium·P Gailly, M Colson-Van Schoor
Jan 13, 2006·Journal of Psychopharmacology·Rainald MössnerJürgen Deckert
May 25, 2005·The Pharmacogenomics Journal·H M FentressE Sanders-Bush
Aug 19, 2007·Human Psychopharmacology·Vincenzo De LucaJames L Kennedy
Sep 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduard Maron, Jakov Shlik
Jul 29, 2010·Expert Review of Neurotherapeutics·C JacobJuergen Deckert
Nov 8, 2020·Genes·Artemii TretiakovEugene Klimov