PMID: 966401Jan 1, 1976Paper

Novel action of a piperazine derivative on the end-plate of the frog

The Japanese Journal of Physiology
K KubaK Koketsu


The effects of a piperazine derivative, trimetazidine (1-(2, 3, 4-trimethoxybenzyl) piperazine dihydrochloride) on the frog end-plate membrane were studied. Action and resting membrane potentials and the input resistance of muscle fibers were not affected by trimetazidine (82-165 muM). Under these conditions, the frequency of the miniature endplate potentials was unchanged while its amplitude was slightly decreased. The amplitude of acetylcholine (ACh) potentials were markedly and reversibly decreased after application of trimetazine (82-165 muM). The dose response curve of the end-plate membrane to ACh showed a non-competitive type of blockade. Trimetazidine (165 muM) not only decreased the amplitude of the end-plate currents (EPC) recorded from the glycerinated muscles using a voltage clamp technique, but also drastically shortened its time course. Under these conditions, the falling phase of the EPC became completely voltage insensitive. The equilibrium potential for the EPC slightly shifted to a more negative value in the presence of trimetazine (165 muM). Coefficient of variation of EPC was increased by Trimetazidine (165 mum), indicating a decrease in the quantal content of the EPC. The rate of desensitization of the end-...Continue Reading


Mar 18, 1983·European Journal of Pharmacology·T AkasuK Koketsu
Jun 1, 1978·Neuropharmacology·K KaibaraA G Karczmar
Jan 1, 1978·Progress in Neurobiology·K Kuba, K Koketsu
May 1, 1985·British Journal of Pharmacology·M AriyoshiT Tokimasa

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