Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers

Polymers
Jie ZhaoXiulin Zhu

Abstract

Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H2O2 or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H2O2 or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.

References

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Citations

Feb 6, 2021·Topics in Current Chemistry·Javad TavakoliYouhong Tang
Aug 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yihenew Simegniew Birhan, Hsieh-Chih Tsai

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Methods Mentioned

BETA
biosensing
infrared spectroscopy
X-ray
scanning electron microscopy
column chromatography
NMR
Fluorescence

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