Nov 11, 2009

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France

Antimicrobial Agents and Chemotherapy
Delphine GirlichPatrice Nordmann

Abstract

A Pseudomonas fluorescens isolate (PF-1) resistant to carbapenems was recovered during an environmental survey performed with water from the Seine River (Paris). It expressed a novel Ambler class A carbapenemase, BIC-1, sharing 68 and 59% amino acid identities with beta-lactamases SFC-1 from Serratia fonticola and the plasmid-encoded KPC-2, respectively. beta-Lactamase BIC-1 hydrolyzed penicillins, carbapenems, and cephalosporins except ceftazidime and monobactams. The bla(BIC-1) gene was chromosomally located and was also identified in two other P. fluorescens strains isolated from the Seine River 3 months later.

  • References23
  • Citations36

Mentioned in this Paper

Monobactams
Carbapenemase
Bacterial Proteins
Ceftazidime
Carbapenems
Cephalosporins
Southern Blot Result
Beta-Lactamase
Gram-Negative Bacteria
Isolate compound

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