Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione

Bioorganic & Medicinal Chemistry
Xiaopan ZhangWenfang Xu

Abstract

Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel APN inhibitors with 3-phenylalanyl-N'-substituted-2,6-piperidinedione scaffold. The results showed that compound 7c had the most potent inhibitory activity against APN with the IC(50) value to 5.00 +/-3.17 microM, which could be used as the lead compound in the future for anticancer agent research.

References

Apr 15, 1995·Cellular Immunology·T H Piela-Smith, J H Korn
Jul 6, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Yuko OnoharaTadashi Yoshimoto

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Citations

May 31, 2011·Expert Opinion on Therapeutic Patents·Li SuWenfang Xu
Apr 10, 2018·Journal of Medicinal Chemistry·Sk Abdul AminTarun Jha

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