PMID: 25030879Jul 18, 2014

Novel and effective balanced intravenous-inhalant anaesthetic protocol in swine by using unrestricted drugs

Experimental Animals
Luigino CalzettaMaurizio Mattei

Abstract

Nowadays, because of increasing employment of swine for experimental studies and medical training, it is hopeful to investigate novel and effective anaesthetic protocols for preserving the animal welfare in medical investigation and concurrently improving the quality of research. Therefore, the aim of this study was to investigate a novel and effective anaesthetic protocol in swine undergoing major surgery, by translating know-how of combined anaesthesia from human protocols. Seven landrace swine were anaesthetized for three hours by a combined trial anaesthetic protocol (sedation: medetomidine, acepromazine, atropine and tramadol; induction: propofol, medetomidine and acepromazine; anaesthesia: isofluorane, propofol, medetomidine and acepromazine) and both clinical and haemodynamic parameters were compared with those of five swine anaesthetized with a control protocol (sedation: diazepam, ketamine and atropina; induction: diazepam and ketamine; anaesthesia: isofluorane). Both cardiac frequency (CF) and mean blood pressure (MBP) were significantly (P<0.05) more stable in trial protocol (CF: 78.3 ± 4.6-81.1 ± 5, MBP: 63.9 ± 10.7-96.4 ± 13.0) compared to control protocol (CF: 93.7 ± 5.5-102.5 ± 8.5, MBP: 71.0 ± 6.6-108.7 ± 7.2). ...Continue Reading

References

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Citations

May 10, 2015·Research in Veterinary Science·Guadalupe López-RoblesJesús Hernández
Apr 6, 2017·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Piero RossiGiuseppe Vespasiani

Related Concepts

Insufflation Anesthesia
Anesthesia, Intravenous
Anesthetic Effect
Metazoa
Animal Cruelty
Drug Interactions
Hemodynamics
Respiration
Safety
Family suidae

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