PMID: 18198484Jan 17, 2008Paper

Novel and extensive aspects of paraquat-induced pulmonary fibrogenesis: comparative and time-course microarray analyses in fibrogenic and non-fibrogenic rats

The Journal of Toxicological Sciences
Yoshihide SatomiFumiaki Akahori

Abstract

Although paraquat (PQ) is widely known to induce pulmonary fibrosis, the molecular mechanisms are poorly understood. Therefore, to bring a new dimension to the elucidation of the mechanisms, we conducted microarray experiments to investigate the expression profiles of 1,090 genes in the lungs during the progressive phase of PQ-induced pulmonary fibrosis in rats. After several s.c. injections of PQ, rats were divided into a fibrogenic group and a non-fibrogenic group. Time-course gene expression analysis of the fibrogenic group showed altered gene regulation throughout the experimental period. The expression levels of many cell membrane channel, transporter, and receptor genes were substantially altered. These genes were classified into two categories: polyamine transporter- and electrolyte/fluid balance-related genes. Moreover, comparative analysis of the fibrogenic and the non-fibrogenic group revealed 36 genes with significantly different patterns of expression, including the pro-apoptotic gene Bad. This indicates that Bad is a key factor in apoptosis and that apoptosis provides a major turning point in PQ-induced pulmonary fibrosis. Notably, subtypes of transforming growth factor (TGF)-beta genes that are considered to play ...Continue Reading

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Citations

Dec 4, 2013·Lung·Elizabeth Lage BorgesMaria da Glória Rodrigues-Machado
Oct 12, 2010·The Journal of Toxicological Sciences·Masayuki OhbayashiToshinori Yamamoto
Dec 3, 2009·The Journal of Toxicological Sciences·Ana Cristina Rodrigues LacerdaCândido Celso Coimbra
Jul 25, 2014·European Journal of Pharmacology·Leila SafaeianGolnaz Vaseghi
Jan 1, 2012·World Journal of Emergency Medicine·Zhi-Jian ZhangCong-Yang Zhou

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