PMID: 7547725May 1, 1995Paper

Novel antiadhesion barrier does not prevent anastomotic healing in a rabbit model

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
M MedinaS D Schwaitzberg

Abstract

Intraperitoneal adhesions following surgical procedures cause considerable morbidity. Hyaluronic acid/carboxymethylcellulose (HA/CMC) films have been shown to be effective agents in decreasing adhesion formation. However, when there is an inadvertent leak of bowel contents into the peritoneum due to incomplete anastomosis, adhesion formation about a defect in order to prevent further leakage and to promote healing of the wound is important for the prevention of morbidity and mortality. The purpose of this study was to determine if an antiadhesion film (HA/CMC) impairs these potentially beneficial adhesions to bowel anastomoses, thus predisposing them to enteric leaks with subsequent peritonitis. Sixty-four rabbits were divided in two groups, each undergoing a complete or partial (90% anastomosis to simulate anastomotic leak) large bowel anastomosis. Half of each of the above groups were treated by wrapping a HA/CMC film over the anastomosis and the other half were untreated controls. These two subgroups were then further divided equally and sacrificed at either 7 or 14 days for evaluation of anastomosis integrity and strength. The average anastomotic bursting pressures did not change significantly between those groups treated w...Continue Reading

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Citations

Mar 25, 2000·Diseases of the Colon and Rectum·A UzunköyA Kocyigit
Aug 22, 2012·International Journal of Colorectal Disease·Hans-Christian PommergaardJacob Rosenberg
Jul 2, 2014·The Journal of Surgical Research·Ankit A ChaturvediHarry van Goor
Mar 16, 2016·Nature Reviews. Urology·Nikolai A Sopko, Arthur L Burnett
Jan 27, 2004·The Veterinary Clinics of North America. Equine Practice·Randall B Eggleston, P O Eric Mueller
May 16, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Keith E GreenawaltThomas H Jozefiak
Jul 10, 2007·International Journal of Surgery·Emre Ergul, Birol Korukluoglu
Dec 17, 2014·International Journal of Surgery·Tebessum CakirMusa Akoglu
Oct 18, 2015·Surgical Innovation·Dimitrios NtourakisAnastasios Machairas
Oct 5, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H C PommergaardM P Achiam
Oct 19, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hiroyuki TsujimotoAkeo Hagiwara
Jun 29, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·B BacaA Dirican
Aug 11, 2001·American Journal of Veterinary Research·R B EgglestonM E Rainbow
Apr 5, 2012·Journal of Tissue Engineering and Regenerative Medicine·Elise DemangeJean-Pierre Vannier
Feb 28, 2018·Annals of the Royal College of Surgeons of England·J TrotterJ MacFie
Jun 6, 2017·Surgical Infections·Ankit A ChaturvediHarry van Goor

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