Novel anticancer agents, kayeassamins C-I from the flower of Kayea assamica of Myanmar

Bioorganic & Medicinal Chemistry
Nwet Nwet WinShigetoshi Kadota

Abstract

A CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica from Myanmar exhibited 100% preferential cytotoxicity (PC(100)) against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded nine new coumarins, kayeassamins A (8), B (9), and C-I (1-7), together with nine known coumarins (10-18). The structures of these compounds were identified by extensive spectroscopic techniques as well as by comparison with published data. Absolute configuration at C-1' of 1 was established as S-configuration by the modified Mosher method. All the isolates were evaluated for their in vitro preferential cytotoxicity using novel anti-austerity strategy. Among them, the novel coumarins, kayeassamins A (8), B (9), D (2), E (3), and G (5) exhibited the most potent preferential cytotoxicity (PC(100) 1 microM) in a concentration- and time-dependent manner and induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment. Based on the observed cytotoxicity, structure-activity relationships have been established.

References

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Citations

Oct 25, 2012·Journal of Natural Products·Suresh AwaleRyuta Miyatake
Nov 6, 2012·BMC Complementary and Alternative Medicine·Rand R HafidhZamberi Sekawi
Jan 1, 2014·Drug Design, Development and Therapy·Jun-ya UedaSuresh Awale
Nov 26, 2015·Journal of Natural Products·Nwet Nwet WinHiroyuki Morita
Sep 4, 2015·Journal of Natural Products·Nwet Nwet WinHiroyuki Morita
Sep 7, 2020·Journal of Ethnopharmacology·Yunn Mi Mi KyawXuefei Yang
Aug 20, 2009·Journal of Natural Products·Suresh AwaleShigetoshi Kadota
May 23, 2009·The Journal of Organic Chemistry·Jakob Magolan, Mark J Coster
Apr 29, 2015·Journal of Natural Products·Nwet Nwet WinHiroyuki Morita

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