Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism.

Metal-based Drugs
Alois KozubíkJirina Hofmanová

Abstract

The impressive impact of cisplatin on cancer on one side and severe side effects, as well as the development of drug resistance during treatment on the other side, were the factors motivating scientists to design and synthesize new more potent analogues lacking disadvantages of cisplatin. Platinum(IV) complexes represent one of the perspective groups of platinum-based drugs. In this review, we summarize recent findings on both in vitro and in vivo effects of platinum(IV) complexes with adamantylamine. Based on a literary overview of the mechanisms of activity of platinum-based cytostatics, we discuss opportunities for modulating the effects of novel platinum complexes through interactions with apoptotic signaling pathways and with cellular lipids, including modulations of the mitochondrial cell death pathway, oxidative stress, signaling of death ligands, lipid metabolism/signaling, or intercellular communication. These approaches might significantly enhance the efficacy of both novel and established platinum-based cytostatics.

References

Jan 1, 1992·The Journal of General Virology·J L RiechmannJ A García
Jul 19, 1989·Journal of the National Cancer Institute·H Timmer-BosschaE G de Vries
May 1, 1984·Annals of Internal Medicine
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J BrouwerJ Reedijk
Apr 1, 1994·Anti-cancer Drugs·H Sasaki, M Fukushima
Jun 4, 1997·Journal of the National Cancer Institute·O MicheauM T Dimanche-Boitrel
Aug 26, 1997·Biochemistry·G SpeelmansB de Kruijff
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R P Perez
Feb 3, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·P K WorkingN Turner
Nov 27, 1999·Pharmacology & Therapeutics·D P Rose, J M Connolly
Feb 17, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Bekradda, E Cvitkovic
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·H KinoshitaK Tasaka
Jan 6, 2001·Journal of Drug Targeting·Y Cao, M R Suresh
Jul 4, 2001·Nature Medicine
Jul 4, 2001·Nature Medicine·G Kenyon
Jul 4, 2001·Nature Medicine·S O'Rahilly
Jul 4, 2001·Nature Medicine·R K Jain
Jul 7, 2001·Molecular Biotechnology·M J Humphries
Jul 27, 2001·American Journal of Respiratory Cell and Molecular Biology·W LiuV C Broaddus
Sep 5, 2001·Nature Medicine·J Price
Oct 9, 2001·Nature Medicine·O Smithies
Oct 9, 2001·Nature Medicine·M R Capecchi
Nov 17, 2001·Current Opinion in Pharmacology·F Bunz
Nov 21, 2001·Japanese Journal of Cancer Research : Gann·H Toriyama-BabaH Tsuda

❮ Previous
Next ❯

Citations

Nov 2, 2011·Proteome Science·Pavel BouchalBorivoj Vojtesek
Jun 8, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Paola GramaticaDomenico Osella
Sep 8, 2016·Journal of Medicinal Chemistry·Aiman Abu AmmarSimon Benita
Apr 20, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Milos ArsenijevicVladislav Volarevic

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Metal Ions in Biological Systems
Matthew D HallTrevor W Hambley
Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Matthew D HallTrevor W Hambley
Journal of Medicinal Chemistry
Matthew D HallTrevor W Hambley
© 2022 Meta ULC. All rights reserved