Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats

Psychopharmacology
Xiu-Ling ZhuYa-Ping Lu

Abstract

Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor (BDNF) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. Paeonol is a kind of polyphenols natural product with a variety of therapeutic effects. Recent studies have reported its antidepressant effects. However, it is unclear what signaling pathways contribute to improve MDD. The present study investigated the effect of Paeonol on hippocampal neuronal morphology and its possible signaling pathways in chronic unpredictable mild stress (CUMS) rat model. Using CUMS rat model, the antidepressant-like effect of Paeonol was validated via depression-related behavioral tests. Neuronal morphology in hippocampal CA1 and DG was assessed using ImageJ's Sholl plugin and RESCONSTRUCT software. BDNF signaling pathway-related molecules was determined by Western blotting. Paeonol attenuated CUMS-induced depression-like behaviors, which were accompanied by hippocampal neuronal morphological alterations. After Paeonol treatment for 4 weeks, the dendritic length and complexity and the density of dendritic spines markedly increased in the hi...Continue Reading

References

Jul 1, 1983·Thrombosis Research·A HiraiA Kumagai
Apr 2, 1999·Trends in Pharmacological Sciences·C A Altar
Feb 5, 2002·Annual Review of Physiology·Esther A NimchinskyKarel Svoboda
Feb 26, 2003·Cell·Thomas D Pollard, Gary G Borisy
Jul 10, 2003·Trends in Neurosciences·Haruo KasaiHiroyuki Nakahara
May 20, 2005·Cerebral Cortex·Jason J RadleyJohn H Morrison
Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 25, 2006·Toxicology and Applied Pharmacology·Kazuhiro IshiguroHidemi Goto
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Martin J SadowskiThomas Wisniewski
May 15, 2007·Current Opinion in Neurobiology·Jennifer Bourne, Kristen M Harris
May 19, 2007·Brain, Behavior and Evolution·K W S AshwellC R R Watson
May 24, 2008·European Journal of Cell Biology·Marleen Van TroysChristophe Ampe
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jul 7, 2009·Annual Review of Psychology·Benedetta Leuner, Elizabeth Gould
Feb 6, 2010·Trends in Cell Biology·Barbara W Bernstein, James R Bamburg
Apr 17, 2010·Chemistry & Biodiversity·Chun-Nian HePei-Gen Xiao
Oct 22, 2010·Canadian Journal of Physiology and Pharmacology·Qiang DuJian-Kang Cai
May 7, 2011·The International Journal of Neuroscience·Ioannis A MavroudisStavros J Baloyannis
Jun 23, 2011·Journal of Clinical Psychopharmacology·Daniel SoueryJulien Mendlewicz
Oct 5, 2011·Reviews in the Neurosciences·Daniel J ChristoffelScott J Russo
Mar 13, 2012·Pharmacological Reviews·Anita E Autry, Lisa M Monteggia
Apr 24, 2012·Neuroscience·B Leuner, T J Shors

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Citations

Sep 22, 2020·Chemistry & Biodiversity·Kaveri M AdkiYogesh A Kulkarni
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Aug 30, 2020·Cells·Tasnuva Sarowar, Andreas M Grabrucker

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Methods Mentioned

BETA
GTPases

Software Mentioned

RECONSTRUCT
NIH
NeuronJ
ImageJ
SPSS

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